文章摘要
韩晓颖,王劲松,李小芬,陈秀记.肝硬化门静脉高压患者血清胃蛋白酶原Ⅰ与胃蛋白酶原Ⅱ水平的变化及其临床意义[J].中国临床保健杂志,2017,20(5):589-591.
肝硬化门静脉高压患者血清胃蛋白酶原Ⅰ与胃蛋白酶原Ⅱ水平的变化及其临床意义
Clinical significance of serum pepsinogen Ⅰ and pepsinogen Ⅱ in patients with hepatic cirrhosis and portal hypertension
投稿时间:2017-01-04  
DOI:10.3969/J.issn.1672-6790.2017.05.029
中文关键词: 肝硬化  高血压,门静脉  胃蛋白酶原类
英文关键词: Liver cirrhosis  Hypertension portal  Pepsinogens 〖FL
基金项目:湖北省自然科学基金项目(ZRY1150)
作者单位E-mail
韩晓颖 湖北襄阳市中心医院消化内科,441021 applexm@sina.com 
王劲松 湖北襄阳市中心医院消化内科,441021  
李小芬 湖北襄阳市中心医院消化内科,441021  
陈秀记 湖北襄阳市中心医院消化内科,441021 ashow6437@163.com 
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中文摘要:
      目的 探讨血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)在肝硬化门静脉高压中的临床意义。方法 选取肝硬化门静脉高压症患者93例(观察组),同时选取选取健康体检者90例作为对照组,采用酶联免疫吸附试验检测两组血清PGⅠ和PGⅡ水平。结果 观察组血清PGⅠ和PGⅡ分别为(160.31±21.06) μg/L和(17.32±1.63) μg/L,明显高于对照组,差异有统计学意义(P<0.05);Child-Paugh C级患者PGⅠ和PGⅡ分别为(201.16±32.11) μg/L和(30.21±2.32) μg/L,明显高于A级和B级患者(P<0.05);门静脉主干内径>13 mm患者PGⅠ和PGⅡ分别为(184.22±27.06) μg/L和(21.06±1.42) μg/L,明显高于≤13 mm患者,差异有统计学意义(P<0.05)。结论 肝硬化门脉高压症患者血清PGⅠ和PGⅡ水平升高,与肝功能分级以及肝脏门静脉主干内径有一定的相关性。
英文摘要:
      Objective To investigate clinical significance of the serum pepsinogen Ⅰ (PG Ⅰ),pepsinogen Ⅱ (PG Ⅱ) in patients with hepatic cirrhosis and portal hypertension.Methods 93 patients (observation group) with cirrhosis and portal hypertension were selected in our hospital,and 90 healthy persons as control group,enzyme linked immunosorbent assay was used to detect the levels of serum PG Ⅰ and PG Ⅱ in the two groups.Results The serum levels of PG Ⅰ and PG Ⅱ in observation group were (160.31 ± 21.06) g/L and (17.32 ± 1.63) g/L,significantly higher than the control group,the difference was statistically significant (P< 0.05);The Child-Paugh grade C patients PG Ⅰ and PG Ⅱ were (201.16 ± 32.11) g/L and (30.21 ± 2.32) g/L was significantly higher than that of Grade A and B patients (P < 0.05).The inner diameter of the main portal vein > 13 mm patients with PG Ⅰ and PG Ⅱ were tested (184.22 ± 27.06) g/L and (21.06 ± 1.42) g/L,were significantly higher than that of ≤13 mm patients,the difference was statistically significant (P< 0.05).Conclusion The serum levels of PG Ⅰ and PG Ⅱ are higher in the patients with cirrhosis and portal hypertension,it may be related to the liver function grade and the inner diameter of the main portal vein of the liver.
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