文章摘要
周云,万丹影,钱晓倩,江皓,冯建国.榄香烯注射液联合吉非替尼改善表皮生长因子受体突变非小细胞肺癌晚期患者免疫功能及生活质量的效果[J].中国临床保健杂志,2017,20(5):502-504.
榄香烯注射液联合吉非替尼改善表皮生长因子受体突变非小细胞肺癌晚期患者免疫功能及生活质量的效果
Effect of elemene injection combined with gefitinib on immune function and life quality of advanced elder lung cancer patients with EGFR mutant
投稿时间:2017-03-10  
DOI:10.3969/J.issn.1672-6790.2017.05.006
中文关键词: 肺肿瘤  半萜类  受体,表皮生长因子  老年人
英文关键词: Lung neoplasms  Hemiterpenes  Receptor,epidermal growth factor  Aged〖FL
基金项目:浙江省医药卫生科研项目(2013KYA028,5KYA035);浙江省自然基金项目(LY13H160028)
作者单位E-mail
周云 浙江省肿瘤医院肿瘤研究所,杭州 310022 mdtlab@zjcc.org.cn 
万丹影 浙江省肿瘤医院肿瘤研究所,杭州 310022  
钱晓倩 浙江省肿瘤医院肿瘤研究所,杭州 310022  
江皓 浙江医院肿瘤科  
冯建国 浙江省肿瘤医院肿瘤研究所,杭州 310022  
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中文摘要:
      目的 研究榄香烯注射液联合吉非替尼对表皮生长因子受体(EGFR)突变晚期非小细胞肺癌患者免疫功能及生活质量的影响。方法 120例晚期非小细胞肺癌患者采用随机数字表法分为治疗组和对照组各60例,治疗组采用榄香烯注射液联合吉非替尼,对照组采用吉非替尼治疗。4周后分别观察两组治疗前后机体免疫状态及生活质量的变化。结果 治疗组总有效率83.3%,对照组总有效率78.3%(P>0.05)。治疗组较对照组CD8+细胞率明显下降,CD4+/CD8+细胞比例上升(P<0.05),治疗组患者卡氏评分、食欲及体质量明显优于对照组(P<0.05)。结论 榄香烯注射液可增强晚期非小细胞肺癌患者免疫功能,改善体力状况及生活质量。
英文摘要:
      Objective To explore the effect of Elemene injection combined with Gefitinib on immune function and life quality of advanced elder lung cancer patients with EGFR mutant.Method 120 patients were randomly divided into two groups.The treatment group with 60 patients were treated with Elemene injection and Gefitinib while the control group with 60 patients were treated with Gefitinib only.After 4 weeks,the changes on immune function and life quality were recorded.Result Compared with control group,the rate of CD8+ cells decreased but CD4+/CD8+ increased significantly in treatment group(P<0.05).There were significant differences in KPS,appetite and body weight between two groups(P<0.05).Conclusion Elemene injection can enhance immune function and improve life quality in elder patients with advanced lung cancer.
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