文章摘要
刘康生,陈娟,孙二虎,顾平清.血清人附睾上皮分泌蛋白4、CA125和卵巢恶性肿瘤风险模型在卵巢癌疾病中的诊断价值[J].中国临床保健杂志,2016,(1):58-60.
血清人附睾上皮分泌蛋白4、CA125和卵巢恶性肿瘤风险模型在卵巢癌疾病中的诊断价值
The diagnosis value of serum human epididymis secretory protein 4,CA125 and risk model of ovarian malignancy algorithm(ROMA) inovarian cancer
投稿时间:2015-04-10  
DOI:10.3969/J.issn.1672-6790.2016.01.019
中文关键词: 心血管疾病  代谢综合征  随访研究
英文关键词: Ovarian neoplasms  Epididymal secretory proteins  CA-125 Antigen 〖FL
基金项目:
作者单位E-mail
刘康生 江苏南京市妇幼保健医院,,南京 210029 liukansheng@sohu.com 
陈娟 江苏南京市妇幼保健医院,,南京 210029  
孙二虎 江苏南京市妇幼保健医院,,南京 210029  
顾平清 江苏南京市妇幼保健医院,,南京 210029  
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中文摘要:
      目的 探讨血清人附睾上皮分泌蛋白4
英文摘要:
      Objective To explore the diagnosis value of combined serum human epididymis protein 4 (HE4),carbohydrate antigen CA125 with ROMA index in ovarian cancer.Methods The patients with ovarian cancer were diagnosed confirmed by histological examination from biopsy.Sixty-four cases of ovarian cancer(A group)and 120 cases of benign ovarian disease(B group) were selected.And 38 healthy subjects were selected as control group(C group).The difference in HE4,CA125 between the groups were analyzed,combine with with menopause status;based on the value of ROMA index predicted the incidence of ovarian cancer.HE4 and CA125 were detected by enzyme-linked immunoassay (ELISA) and chemiluminescence.Results The serum levels of HE4,CA125 and ROMA in patients with ovarian cancer were significantly higher than those in controls(P<0.05).The serum levels of CA125 and ROMA in patients with benign ovarian disease were significantly higher than those in healthy subjects(P<0.05).The serum HE4 between benign ovarian disease group and control group was not statistically significant (P>0.05).The Specificity and sensitivity of HE4、CA125、ROMA were 98.33%,80.80%,82.50% and 75.00%,65.62%,81.25%,respectively.The specificity of HE4 was best,the sensitivity of ROMA was best.The positive rate of serum HE4 was associated with age,ROMA was associated with age and menopausal status (P<0.05).Conclusion The serum levels of HE4、CA125 and ROMA index may be a helpful method to assess the risk of epithelioid ovarian cancer.
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