文章摘要
宋诗涛,董吉云,王锋,杨志勇,陈继群,苗连海.血清胱抑素C联合尿白蛋白与肌酐比值对老年2型糖尿病肾损害的早期诊断[J].中国临床保健杂志,2016,(1):56-57.
血清胱抑素C联合尿白蛋白与肌酐比值对老年2型糖尿病肾损害的早期诊断
The early diagnostic value of serum CysC and urinary albumin/Cr in elderly diabetic renal damage
投稿时间:2015-09-23  
DOI:10.3969/J.issn.1672-6790.2016.01.018
中文关键词: 糖尿病肾病  肾小球滤过率  白蛋白尿  半胱氨酸蛋白酶抑制物C
英文关键词: Diabetic nephropathies  Glomerular filtration rate  Albuminuria  Cystatin C 〖FL
基金项目:
作者单位E-mail
宋诗涛 安徽合肥市第三人民医院老年病科,230022 sstao0907@163.com 
董吉云 安徽合肥市第三人民医院老年病科,230022 djy3511472@163.com 
王锋 安徽合肥市第三人民医院老年病科,230022  
杨志勇 安徽合肥市第三人民医院老年病科,230022  
陈继群 安徽合肥市第三人民医院老年病科,230022  
苗连海 安徽合肥市第三人民医院老年病科,230022  
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中文摘要:
      目的 探讨血清胱抑素C(Cys C)和尿中白蛋白(Alb)与肌酐(Cr)比值(UACR)对诊断老年2型糖尿病患者早期肾脏损害的临床价值。方法 选择60岁以上尿蛋白阴性的2型糖尿病患者60例,其中血肌酐水平正常的30例(A组),血肌酐明显升高的30例(B组);同时纳入30例同期于我院门诊体检的60岁以上的健康人群作为对照组。采用免疫透射比浊法测定血清Cys C含量,免疫浊度法测定尿Alb含量,全自动生化分析仪同时测定血清Cr和尿Cr。结果 老年糖尿病患者的血清Cys C和UACR均明显高于健康对照组,差异有统计学意义(P<0.05);且联合检测的敏感性和特异性更高(相比较于单项检测,P<0.05)。结论 血清Cys C和UACR可以作为诊断老年2型糖尿病患者早期肾损害的敏感和特异性指标,两者联合检测对老年糖尿病患者早期肾损害的诊断有重要价值。
英文摘要:
      Objective To explore the clinical value of serum cystatin C and urinary albumin(UAlb)/Cr(UACR)as a early diagnosis index for the elderly diabetic with early renal damage.Methed Sixty cases of type 2 diabetes (over 60s) without urinary protein were selected,including 30 cases of normal serum creatinine(group A) and 30 patients with increased creatinine(group B).Thirty healthy people were selected as control group.Serum CysC and UAlb were detected by immune turbidimetry;serum and urinary Cr were detected by automatic biochemical analyzer.Result Serum CysC and UACR of DM group were significantly higher than those of normal control group(P<0.05).The sensitivity and specificity of combination detection were higher than single.Conclusion The serum CysC and UACR are sensitive indexes of early renal damage,it has important value in the diagnosis of elderly diabetic renal damage.
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