文章摘要
郑芳昆,龙登毅,贝箏,于航.帕金森病患者发生吞咽障碍与肺部感染的相关性及其炎性因子水平的变化[J].中国临床保健杂志,2020,23(6):812-814.
帕金森病患者发生吞咽障碍与肺部感染的相关性及其炎性因子水平的变化
Relationship between dysphagia and pulmonary infection in patients with Parkinson′s disease and changes of inflammatory factors
投稿时间:2020-03-26  
DOI:10.3969/J.issn.1672-6790.2020.06.022
中文关键词: 帕金森病  吞咽障碍  细菌感染,肺  危险因素
英文关键词: Parkinson disease  Deglutition disorders  Bacterial infections,lung  Risk factors 〖FL
基金项目:海南省高等学校科学研究项目(Hnky2018-50)
作者单位E-mail
郑芳昆 海南省干部疗养院海南省老年病医院神经内科,海口 571100 zhengfangkun9@163.com 
龙登毅 海南省干部疗养院海南省老年病医院神经内科,海口 571100  
贝箏 海南省干部疗养院海南省老年病医院神经内科,海口 571100  
于航 海南医学院第二附属医院重症医学科  
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中文摘要:
      目的 探讨帕金森病患者的吞咽障碍与肺部感染的相关性及炎性因子水平变化。方法 选择海南省干部疗养院于2015年9月至2019年12月期间收治的帕金森病患者120例作为研究对象,根据是否发生吞咽障碍分为吞咽障碍组(n=85)与非吞咽障碍组(n=35)。观察所有研究对象肺部感染发生情况及病原菌分布情况,是否合并吞咽障碍肺部感染和炎性因子水平变化。结果 120例帕金森病患者中,发生肺部感染患者47例,发生率为39.17%。肺部感染患者分离病原菌48株,其中分离出革兰阴性菌29株,分离出革兰阳性菌19株。吞咽障碍组肺部感染率(49.41%)高于非吞咽障碍组(14.28%),差异有统计学意义(P<0.05)。吞咽障碍组血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平高于非吞咽障碍组,差异有统计学意义(P<0.05)。结论 帕金森病患者吞咽障碍发生率较高,且与肺部感染密切相关,且吞咽障碍患者血清IL-1β、IL-6和TNF-α水平明显升高。
英文摘要:
      Objective To investigate the relationship between dysphagia and pulmonary infection in patients with Parkinson′s disease and the changes of inflammatory factors.Methods The 120 patients with Parkinson′s disease admitted to our hospital from September 2015 to December 2019 were selected as the study subjects.According to the occurrence of dysphagia,they were divided into dysphagia group (n=85) and non-dysphagia group (n=35).The incidence of pulmonary infection and the distribution of pathogenic bacteria in all subjects were observed,and the changes of pulmonary infection and inflammatory factors were observed.Results 120 patients with Parkinson′s disease,47 had pulmonary infection,the incidence was 39.17%,48 strains of pathogenic bacteria were isolated from patients with pulmonary infection,29 of them were Gram-negative bacteria and 19 were Gram-positive bacteria.The rate of pulmonary infection in dysphagia group (49.41%) was higher than that in non-dysphagia group (14.28%),P<0.05.The serum levels of IL-1beta,IL-6 and TNF-a in dysphagia group were higher than those in non-dysphagia group (P<0.05).Conclusion The incidence of dysphagia in Parkinson′s disease patients is higher,which is closely related to pulmonary infection with significant increased serum IL-1,IL-6,and TNF-α levels.
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