文章摘要
张学敏,王锦锦,李稳静,王书,刘玉,谢军,余其贵,张颖,吴泽兵,胡世莲.老年高血压患者血压变异性与血管紧张素(1-7)的相关性[J].中国临床保健杂志,2020,23(6):785-789.
老年高血压患者血压变异性与血管紧张素(1-7)的相关性
Study on the relationship of blood pressure variation in elderly hypertensive patients with angiotensin (17)
投稿时间:2020-09-04  
DOI:10.3969/J.issn.1672-6790.2020.06.015
中文关键词: 血压变异性  血管紧张素(1-7)  高血压  老年人
英文关键词: BPV  Ang(1-7)  Hypertension  Aged
基金项目:中央引导地方科技发展专项资金项目(2019b11030012,2019b12030026);安徽省科技攻关项目(1501041142);安徽省合肥市卫生计生委2016年应用医学研究项目(hwk2016yb001)
作者单位E-mail
张学敏 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061 1193093241@qq.com 
王锦锦 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061  
李稳静 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061  
王书 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061  
刘玉 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061  
谢军 安徽合肥市第二人民医院全科医学科  
余其贵 安徽合肥市第二人民医院全科医学科  
张颖 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061  
吴泽兵 安徽医科大学第三附属医院合肥市第一人民医院老年病科,合肥 230061 wuzebing@sina.com 
胡世莲 中国科学技术大学附属第一医院(安徽省立医院)
安徽省老年医学研究所
肿瘤免疫与营养治疗安徽省重点实验室 
 
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中文摘要:
      目的 分析老年高血压患者血压变异性(BPV)与血管紧张素(1-7)的变化并探讨两者之间的关系。方法 选取安徽医科大学第三附属医院老年病科门诊2、3级老年高血压患者52例为高血压组,体检血压正常的老年人50例入选为对照组,入选病人均检测血脂、空腹血糖(FPG)、血尿酸(UA),酶联免疫吸附剂测定(ELISA)法检测血浆Ang(1-7)水平,监测24 h动态血压。结果 (1)对照组、高血压组患者在性别、年龄、吸烟史、血清三酰甘油(TG)、血清胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、FPG、UA、诊室收缩压、诊室舒张压差异均无统计学意义(P>0.05)。(2)对照组与高血压组的24小时收缩压(24hSBP)、24小时舒张压(24hDBP)、白昼收缩压(dSBP)、白昼舒张压(dDBP)、夜间收缩压(nSBP)、夜间舒张压(nDBP)差异均无统计学意义(P>0.05)。(3)对照组与高血压组的24小时收缩压变异性(24hSBPV)、24小时舒张压变异性(24hDBPV)、白昼收缩压变异性(dSBPV)、白昼舒张压变异性(dDBPV)、夜间收缩压变异性(nSBPV)差异均有统计学意义(P<0.05)。(4)对照组与高血压组Ang(1-7)差异有统计学意义(P<0.01)。(5)对照组与高血压组的Ang(1-7)与24hSBPV均有相关性,与24hDBPV、dSBPV、dDBPV、nSBPV、夜间舒张压变异性(nDBPV)无相关性(P值均>0.05)。结论 老年高血压患者BPV增大、Ang(1-7)水平减低,且Ang(1-7)的水平降低与24hSBPV升高密切相关。
英文摘要:
      Objective To analyze the relationship between blood pressure variability (BPV) and angiotensin(1-7) in elderly hypertensive patients.Methods Fifty-two elderly patients with grade 2 and grade 3 hypertension in the geriatrics outpatient department of the Third Affiliated Hospital of Anhui Medical University were selected as the hypertension group,and 50 elderly patients with normal blood pressure were selected as the control group.All the selected patients were tested for blood lipids,fasting blood glucose (FPG) and blood uric acid (UA),Enzyme-linked immunosorbent assay (ELISA) method was used to detect plasma Ang(1-7) levels and 24 h ambulatory blood pressure were monitored.Results (1)Gender,age,smoking history,serum triglyceride (TG),serum cholesterol (TC),low density lipoprotein (LDLC),high density lipoprotein (HDL-C),FPG,UA,office systolic blood pressure,and office diastolic blood pressure were not significantly different between two groups (P>0.05).(2)24-hour systolic blood pressure (24hSBP),24-hour diastolic blood pressure (24hDBP),day systolic blood pressure (dSBP),day diastolic blood pressure (dDBP),night systolic blood pressure (nSBP) and night diastolic blood pressure (nDBP) were not statistically significant between two groups (P>0.05).(3)24-hour systolic blood pressure variability (24hSBPV),24-hour diastolic blood pressure variability (24hDBPV),day systolic blood pressure variability (dSBPV),daytime diastolic blood pressure variability (dDBPV),night systolic blood pressure.The differences in variability (nSBPV) were statistically significant between control group and hypertension group (P<0.05).(4)There was a statistically significant difference in Ang(1-7) between the control group and the hypertension group (P<0.01).(5)The Ang(1-7) of the control group and the hypertension group were correlated with 24hSBPV,but not correlated with 24hDBPV,dSBPV,dDBPV,nSBPV,night diastolic blood pressure variability (nDBPV) (all P>0.05).Conclusion In elderly hypertensive patients,BPV increases and Ang(1-7) levels decrease,and the decrease of Ang(1-7) levels is closely related to the increase of 24h SBPV.
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