文章摘要
张艳华,李晓玲,李增宁.国内恶性肿瘤患者营养不良影响因素 Meta 分析[J].中国临床保健杂志,2020,23(5):649-655.
国内恶性肿瘤患者营养不良影响因素 Meta 分析
Meta-analysis of the factors affecting malnutrition in patients with domestic malignant tumor
投稿时间:2020-06-17  
DOI:10.3969/J.issn.1672-6790.2020.05.018
中文关键词: 肿瘤  营养不良  影响因素分析  Meta分析
英文关键词: Neoplasms  Malnutrition  Root cause analysis  Meta-analysis 〖FL
基金项目:河北省重点研发计划项目健康医疗与生物医药专项(182777127D)
作者单位E-mail
张艳华 河北涿州市医院肿瘤内一科,072750 lizengning@126.com 
李晓玲 河北医科大学第一医院营养科 lizengning@126.com 
李增宁 河北医科大学第一医院营养科 lizengning@126.com 
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中文摘要:
      目的 系统分析国内恶性肿瘤患者营养不良影响因素,为制订预防恶性肿瘤患者的营养不良方案提供依据。方法 检索中国生物医学文献数据库(CBM)、中国知识基础设施工程(CNKI)、万方、维普、PubMed以及Embase 数据库中国内恶性肿瘤患者营养不良影响因素的相关文献,提取数据进行Meta分析。结果 共纳入2001—2020 年来自国内的24个横断面研究,恶性肿瘤患者7 079例,其中发生营养不良3 890例。宿主因素发生营养不良的Meta分析合并值:男性、年龄<70岁的OR值及95%CI分别为1.01(0.78~1.31)、0.34(0.23~0.51)。肿瘤因素发生营养不良的Meta分析合并值:消化道肿瘤、肿瘤分期为Ⅰ—Ⅱ期的OR值及95%CI分别为3.29(2.20~4.93)、0.56(0.38~0.84)。治疗因素发生营养不良的 Meta分析合并值:无化疗、无营养支持的OR值及95%CI分别为0.88(0.54~1.45)、0.93(0.48~1.79)。结论 恶性肿瘤患者的营养不良影响因素复杂多样,本研究表明年龄≥70岁、发生在消化道部位、肿瘤分期在Ⅲ—Ⅳ期、化疗均为国内恶性肿瘤患者发生营养不良的高危因素。
英文摘要:
      Objective To analyses the factors of malnutrition in domestic malignant tumor patients and provides a basis for the formulation of malnutrition prevention programs for malignant tumor patients.Method The related articles of the factors affecting malnutrition in patients with malignant tumors in China were retrieved from China Biology Mecicine(CBM),China National Knowledge Infrastructure(CNKI),Wanfang database,Vip database,PubMed,and Embase,all data were conducted Meta-analysis.Results A total of 24 cross-sectional studies from 2001 to 2020 were conducted in China.There were 7 079 cases of malignant tumors,of which 3 890 were cases of malnutrition.Meta-analysis on combined values of host factors for malnutrition were as follow:OR(95%CI) of male and Age less than 70 were 1.01(0.78-1.31) and 0.34(0.23-0.51),respectively; Meta-analysis on combined values of tumor factors for malnutrition were as follow:OR(95%CI) of gastrointestinal tumors and Ⅰ-Ⅱ of tumor stage were 3.29(2.20-4.93) and 0.56(0.38-0.84),respectively;Meta analysis on combined values of therapeutic factors for malnutrition were as follow:OR(95%CI) of no chemotherapy and no nutritional support were 0.88(0.54-1.45)and 0.93(0.48-1.79),respectively.Conclusion The factors of malnutrition in patients with malignant tumors is complex and varied.The age of ≥70 years old,occurring in the digestive tract,tumors staged in stage Ⅲ-Ⅳ and chemotherapy are all high risk factors for malnutrition in patients with malignant tumors in China.
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