文章摘要
洪芳德,赵韧,马东宇,王邦宁.替格瑞洛联合肝素治疗非ST段抬高型急性冠脉综合征患者的效果及对炎性因子水平的影响[J].中国临床保健杂志,2020,23(5):632-635.
替格瑞洛联合肝素治疗非ST段抬高型急性冠脉综合征患者的效果及对炎性因子水平的影响
Ticagrelor combined with heparin in the treatment of non ST elevation acute coronary syndrome
投稿时间:2020-05-10  
DOI:10.3969/J.issn.1672-6790.2020.05.014
中文关键词: 冠状动脉血栓形成  替格瑞洛  肝素  治疗结果
英文关键词: Coronary thrombosis  Ticagrelor  Heparin  Treatment outcome 〖FL
基金项目:国家自然科学基金面上项目(81970446)
作者单位E-mail
洪芳德 安徽医科大学第一附属医院心血管内科,合肥 230022 627262173@qq.com 
赵韧 安徽医科大学第一附属医院心血管内科,合肥 230022  
马东宇 安徽医科大学第一附属医院心血管内科,合肥 230022  
王邦宁 安徽医科大学第一附属医院心血管内科,合肥 230022  
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中文摘要:
      目的 探讨和分析替格瑞洛联合肝素治疗非ST段抬高型急性冠脉综合征患者的效果及对炎性因子水平的影响。方法 选取安徽医科大学第一附属医院于2019年1月至12月期间收治非ST段抬高型急性冠脉综合征患者106例,按照交叉双盲法分为两组,对照组53例患者给予替格瑞洛治疗方案,观察组53例患者则给予替格瑞洛联合肝素治疗方案。对比两组显效率、有效率、无效率、总体有效率及再通率等临床指标。根据肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)等指标水平,对比两组治疗前后炎性应激状态。根据心脏指数(CI)、每搏量(SV)、左室射血分数(LVEF)等指标及心功能情况。结果 观察组疗效、再通率均高于对照组,组间差异有统计学意义(P<0.05)。治疗前两组TNF-α、IL-6、hs-CRP等指标水平差异无统计学意义,治疗后观察组各项炎性因子水平均低于对照组(P<0.05)。治疗前两组CI、SV、LVEF等指标水平差异无统计学意义,治疗后观察组各项心功能指标水平均优于对照组(P<0.05)。结论 对非ST段抬高型急性冠脉综合征患者实施替格瑞洛、肝素联合治疗,可有效提高临床疗效,降低炎性因子水平,有助于心功能恢复。
英文摘要:
      Objective To explore and analyze the effect of tigril combined with heparin in the treatment of non ST elevation acute coronary syndrome and the level of inflammatory factors.Methods 106 patients with non ST elevation acute coronary syndrome were enrolled in this study.According to the cross double blind method,they were divided into two groups.53 patients in the control group were treated with tegrilol,53 patients in the observation group were treated with tegrilol combined with heparin.The clinical indexes such as apparent efficiency,effective rate,ineffective rate,overall effective rate and recanalization rate were compared between the two groups.According to the levels of TNF-α,IL-6,hs-CRP and other indicators,the inflammatory stress state of the two groups before and after treatment were compared.According to the level of CI,SV,LVEF and other indicators,the cardiac function of the two groups before and after treatment was compared.Results The effective rate and recanalization rate of the observation group were higher than that of the control group,and the difference between the groups was statistically significant (P<0.05).There was no difference in TNF-α,IL-6,hs-CRP between the two groups before treatment.After treatment,the levels of inflammatory factors in the observation group were lower than that in the control group (P<0.05).There was no significant difference in CI,SV and LVEF between the two groups before the treatment (P>0.05).After the treatment,the indexes of heart function in the observation group were better than those in the control group (P<0.05).Conclusion The combination of tigril and heparin can effectively improve the clinical effect and recanalization rate,reduce the level of inflammatory index and help the recovery of heart function.
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