文章摘要
余万里,黎明,罗意,陶海燕,陈宗涛.老年原发性高血压合并类风湿关节炎患者动态血压的昼夜节律及血压变异性[J].中国临床保健杂志,2020,23(5):617-620.
老年原发性高血压合并类风湿关节炎患者动态血压的昼夜节律及血压变异性
Circadian rhythm and variability of ambulate blood pressure in elderly patients with essential hypertension and rheumatoid arthritis
投稿时间:2020-04-30  
DOI:10.3969/J.issn.1672-6790.2020.05.010
中文关键词: 关节炎,类风湿  原发性高血压  昼夜节律
英文关键词: Arthritis,rheumatoid  Essential hypertension  Circadian rhythm 〖FL
基金项目:国家自然科学基金地区科学基金项目(31760327)
作者单位E-mail
余万里 中国人民解放军陆军军医大学第一附属医院健康管理中心,重庆 400031 1980291414@qq.com 
黎明 中国人民解放军陆军军医大学第一附属医院健康管理中心,重庆 400031 1980291414@qq.com 
罗意 中国人民解放军陆军军医大学第一附属医院健康管理中心,重庆 400031 1980291414@qq.com 
陶海燕 中国人民解放军陆军军医大学第一附属医院健康管理中心,重庆 400031 1980291414@qq.com 
陈宗涛 中国人民解放军陆军军医大学第一附属医院健康管理中心,重庆 400031 1980291414@qq.com 
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中文摘要:
      目的 探讨老年原发性高血压(EH)合并类风湿关节炎(RA)患者动态血压的昼夜节律及血压变异性(BPV)。方法 选择2018年1月至2019年10月期间于陆军军医大学第一附属医院就诊合并RA的EH老年患者48例作为病例组,选择同期就诊的单纯EH老年患者40例作为对照组,选择身体健康的老年体检志愿者40例为健康组。采用无创便携式动态血压检测仪监测24 h动态血压变化,记录24hSBP、24hDBP、日平均收缩压(dSBP)、日平均舒张压(dDBP)、夜平均收缩压(nSBP)、夜平均舒张压(nDBP)、血压昼夜节律异常率及各时段的血压标准差与变异系数。结果 与健康组比较,病例组和对照组24hSBP、24hDBP、dSBP、dDBP、nSBP、nDBP均显著较高(P<0.05);病例组nSBP和nDBP显著高于对照组,差异有统计学意义(P<0.05);病例组血压昼夜节律异常率91.67%显著高于对照组57.50%,差异有统计学意义(P<0.05);与健康组比较,病例组和对照组nSBP-SD、nDBP-SD显著较高(P<0.05);病例组nSBP-SD和nDBP-SD显著高于对照组,差异有统计学意义(P<0.05);多元线性回归分析显示,nSBP、nDBP、nSBP-SD、nDBP-SD与EH患者合并RA相关(P<0.05)。结论 合并RA的EH老年患者夜间SBP和DBP明显更高,更易出现昼夜血压节律异常,血压调节功能的损害较大。
英文摘要:
      Objective To study the circadian rhythm and blood pressure variability (BPV) of ambulate blood pressure in elderly patients with essential hypertension (EH) complicated with rheumatoid arthritis (RA).Methods A total of 48 elderly patients with EH and RA in the hospital from January 2018 to October 2019 were selected and included in the case group.Forty elderly patients with EH in the hospital during the same period were selected as the control group.Forty healthy elderly volunteers were selected as normal group.The non-invasive portable ambulatory blood pressure monitor was used to monitor changes in 24h ambulatory blood pressure.The 24hSBP,24hDBP,daily mean SBP (dSBP),daily mean DBP (dDBP),night mean SBP (nSBP),night mean DBP (nDBP),abnormal rate of blood pressure circadian rhythm,standard deviation of blood pressure and variation coefficientin each period were recorded.Results Compared with normal group,the 24hSBP,24hDBP,dSBP,dDBP,nSBP and nDBP were significantly higher in case group and control group (P<0.05).The nSBP and nDBP in case group were significantly higher than those in control group (P<0.05).The abnormal rate of blood pressure circadian rhythm in case group (91.67%) was significantly higher than that in control group (57.50%) (P<0.05).Compared with normal group,nSBP-SD and nDBP-SD were significantly higher in case group and control group (P<0.05).The nSBP-SD and nDBP-SD in case group were significantly higher than those in control group (P<0.05).Multiple linear regression analysis showed that nSBP,nDBP,nSBP-SD and nDBP-SD were related to RA in EH patients (P<0.05).Conclusion The nighttime SBP and DBP are significantly higher in elderly patients with EH and RA.Such patients are more prone to have abnormal blood pressure circadian rhythm and the damage to blood pressure regulation function is relatively bigger.
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