文章摘要
徐志伟,成威,马聪,高彦琳,宋博凡,储时春,赵胜,汪海燕,栗君,汪平.沙库巴曲缬沙坦治疗急性失代偿心力衰竭患者的效果[J].中国临床保健杂志,2020,23(3):403-407.
沙库巴曲缬沙坦治疗急性失代偿心力衰竭患者的效果
Clinical observation on the effect of sacubitril/valsartan in patients with acute decompensated heart failure
投稿时间:2020-01-20  
DOI:10.3969/J.issn.1672-6790.2020.03.029
中文关键词: 心力衰竭  血流动力学  利钠肽,脑  治疗结果  沙库巴曲缬沙坦
英文关键词: Heart failure  Hemodynamics  Natriuretic peptide,brain  Treatment outcome  Sacubitril/valsartan 〖FL
基金项目:安徽省高等学校自然科学研究重点项目(KJ2018A0814)
作者单位E-mail
徐志伟 安徽省第二人民医院心内科,合肥 230041 117346721@qq.com 
成威 安徽省第二人民医院心内科,合肥 230041 ch-wei0403@qq.com 
马聪 安徽省第二人民医院心内科,合肥 230041  
高彦琳 安徽省第二人民医院心内科,合肥 230041  
宋博凡 安徽省第二人民医院心内科,合肥 230041  
储时春 安徽省第二人民医院心内科,合肥 230041  
赵胜 安徽省第二人民医院心内科,合肥 230041  
汪海燕 安徽省第二人民医院心内科,合肥 230041  
栗君 安徽省第二人民医院心内科,合肥 230041  
汪平 安徽省第二人民医院心内科,合肥 230041  
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中文摘要:
      目的 探讨急性失代偿心力衰竭(ADHF)患者血流动力学稳定后院内启用沙库巴曲缬沙坦治疗的临床疗效。 方法 回顾性分析2018年1月1日至2019年6月30日在我科住院的射血分数降低的ADHF患者74例,血流动力学稳定后,接受沙库巴曲缬沙坦治疗,观察并分析治疗前与治疗3个月及6个月的血清学指标、心脏重构指标、心功能分级、6分钟步行距离、血压及肾功能等的变化。 结果 沙库巴曲缬沙坦治疗后,患者N端-B型钠尿肽前体(NT-proBNP)、左室舒张末内径(LVEDD)自3个月即得到改善,6个月时更为显著,治疗前和治疗后6月NT-proBNP[(9147.62±6424.07)pg/mL和(461.65±343.24)pg/mL]和LVEDD[(60.42±9.26)mm和(56.80±9.45)mm]差异均有统计学意义(P<0.01)。患者入院时左室射血分数为33.80%±6.59%,治疗后6个月上升至40.45%±7.84%,差异有统计学意义(P<0.01)。 结论 射血分数降低的ADHF血流动力学稳定后应用沙库巴曲缬沙坦可显著降低NT-proBNP,逆转左心逆重构。
英文摘要:
      Objective To observe the clinical effect of using sacubitril/valsartan to treat acute decompensated heart failure (ADHF) in the hospital after hemodynamic stabilization. Method The patients with ADHF who were hospitalized in our department from January 1,2018 to June 30,2019 were selected retrospectively.After the hemodynamics was stable,they were treated with sacubitril/valsartan.Before and after the treatment for 3 and 6 months,they were observed and analyzed to reflect the serological indicators of heart failure,cardiac remodeling indicators,cardiac function grading,6-minute walk distance (6-MWD),blood pressure and renal function. Results The levels of N terminal pro-B-type natriuretic peptide (NT-proBNP),left ventricular end diastolic diameter (LVEDD) of patients were improved from 3 months after treatment,especially at 6 months.NT-proBNP[(9147.62±6424.07)pg/mL vs (461.65±343.24)pg/mL),P<0.01],LVEDD[(60.42±9.26)mm vs (56.80±9.45)mm,P<0.01] were significantly improved before and 6 months after treatment.The left ventricular ejection fraction (LVEF) was 33.80%±6.59% at the time of admission and increased to 40.45%±7.84% six months after treatment,the difference was statistically significant (P<0.01). Conclusion The application of sacubitril/valsartan after the hemodynamic stability of ADHF with reduced ejection fraction can significantly reduce the levels of NT-proBNP,and reverse the reverse remodeling of left heart.
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