文章摘要
张媛媛,刘怀珍,李居一,牛知影,张进军.2型糖尿病患者尿白蛋白/肌酐比与血清胆红素的相关研究[J].中国临床保健杂志,2020,23(3):400-402.
2型糖尿病患者尿白蛋白/肌酐比与血清胆红素的相关研究
Correlational studies on urinary albumin/creatinine ratio and serum bilirubin in type 2 diabetic patients
投稿时间:2018-01-06  
DOI:10.3969/J.issn.1672-6790.2020.03.028
中文关键词: 糖尿病,2型  糖尿病肾病  胆红素  白蛋白尿
英文关键词: Diabetes mellitus,type 2  Diabetic nephropathies  Bilirubin  Albuminuria 〖FL
基金项目:安徽省卫生计生委中医药科研基金项目(2016ZY12)
作者单位E-mail
张媛媛 安徽中医药大学第一附属医院干部内分泌科,合肥 230031 328283653@qq.com 
刘怀珍 安徽中医药大学第一附属医院干部内分泌科,合肥 230031  
李居一 安徽中医药大学第一附属医院干部内分泌科,合肥 230031  
牛知影 安徽中医药大学第一附属医院干部内分泌科,合肥 230031  
张进军 安徽中医药大学第一附属医院干部内分泌科,合肥 230031  
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中文摘要:
      目的 探讨2型糖尿病(T2DM)患者尿白蛋白/肌酐比(UACR)与血清总胆红素(TBIL)、直接及间接胆红素(DBIL、IBIL)之间的关联性。方法 选择517例住院治疗的T2DM患者,根据UACR分成三组,正常白蛋白尿组(A组)274例,微量白蛋白尿组(B组)167例,大量白蛋白尿组(C组)76例,采用非参数检验法比较三组间血清TBIL、DBIL、IBIL的差异,同时行相关因素分析。结果 B组、C组分别与A组相比,TBIL、DBIL、IBIL水平明显下降;C组与B组相比,TBIL、DBIL 水平明显下降,均P<0.05。在UACR>30 mg/g人群中,UACR的相关分析表明:UACR与病程、收缩压(SBP)、平均动脉压(MAP)、血肌酐(CR)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)呈正相关;UACR与TBIL、DBIL 、IBIL呈负相关,均P<0.05。结论 血清胆红素可能是T2DM患者白蛋白尿的保护因素。
英文摘要:
      Objective To investigate the correlation urinary albumin/creatinine ratio (UACR),serum total bilirubin (TBIL),direct and indirect bilirubin (DBIL,IBIL) in patients with type 2 diabetes mellitus (T2DM). Methods 517 patients with T2DM were enrolled.On the basis of UACR,all patients were divided into three groups:274 cases of normalalbuminuria group (group A),167cases of microalbuminuria group (group B),76cases of macroalbuminuria group (group C).The differences of TBIL,DBIL and IBIL in three groups were compared.Non-parametric test was used to analysize.The correlation factors analysis of UACR was performed. Results The levels of serum TBIL,DBIL and IBIL were significantly decreased in group B and group C,respectively,compared with group A.Compared with group B,serum TBIL and DBIL were significantly decreased in group C,all P<0.05.In the UACR>30 mg/g population,correlation analysis showed that UACR was positively correlated with the course of diabetes,systolic blood pressure (SBP),average arterial pressure (MAP),serum creatinine (CR),total cholesterol (TC),high density lipoprotein (HDL),low density lipoprotein (LDL);UACR was negatively correlated with serum TBIL,DBIL,IBIL,all P<0.05. Conclusion Serum bilirubin maybe a pretective factor for albuminuria in T2DM patients.
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