文章摘要
李文静,汤淑涵,刘佳瑞,陈超,周婉,叶山东.尿白蛋白/尿肌酐比与2型糖尿病下肢血管病变相关性研究[J].中国临床保健杂志,2020,23(3):331-334.
尿白蛋白/尿肌酐比与2型糖尿病下肢血管病变相关性研究
Relationship between urinary albumin-to-creatinine ratio and lower extremity arterial disease in patients with type 2 diabetes mellitus
投稿时间:2020-02-11  
DOI:10.3969/J.issn.1672-6790.2020.03.011
中文关键词: 糖尿病,血管病变,下肢  白蛋白类  肌酸酐  危险因素
英文关键词: Diabetes,angiopathies,lower extremity  Albumins  Creatinine  Risk factors 〖FL
基金项目:国家自然科学基金项目 (81800713) ;安徽省中央引导地方科技发展专项(2017070802D147)
作者单位E-mail
李文静 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥 230001 ysd196406@163.com 
汤淑涵 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥 230001 ysd196406@163.com 
刘佳瑞 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥 230001 ysd196406@163.com 
陈超 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥 230001 ysd196406@163.com 
周婉 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥 230001 ysd196406@163.com 
叶山东 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥 230001 ysd196406@163.com 
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中文摘要:
      目的 探讨尿白蛋白/尿肌酐比值(UACR)与2型糖尿病(T2DM)患者下肢血管病变的关系。方法 选取T2DM患者577例,根据踝肱指数(ABI)分为不合并下肢血管病变组(NLEAD组,472例)和合并下肢血管病变组(LEAD组,105例),收集两组患者的年龄、病程、吸烟史、收缩压、舒张压、体质指数(BMI)和实验室相关指标。结果 LEAD组年龄、病程、吸烟率、收缩压(SBP)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、肌酐(Cr)及UACR高于NLEAD组,而肾小球滤过率(eGFR)低于NLEAD组,差异有统计学意义(P<0.05);两组间舒张压(DBP)、体质指数(BMI)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)差异无统计学意义(P>0.05)。相关分析显示,UACR与年龄、病程、SBP、HbA1c、Cr和UA呈正相关,与eGFR和ABI呈负相关。logistic回归分析结果显示,SBP、LDL-C和UACR是T2DM合并下肢血管病变的危险因素。结论 2型糖尿病患者UACR升高提示下肢血管病变发生的风险增大,定期监测UACR有助于早期预防下肢血管病变。
英文摘要:
      Objective To explore the relationship between urinary albumin-to-creatinine ratio (UACR) and lower extremity arterial disease(LEAD) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 577 patients with T2DM were enrolled.According to the ankle brachial index (ABI),all the participants were divided into non lower extremity arterial disease group ( NLEAD,472 case) and LEAD group (LEAD,105 cases).The age,gender,duration of diabetes,smoking history,systemic blood pressure,diastolic blood pressure,body mass index and laboratory related examination parameters of patients were collected.Results The Age,duration of diabetes,smoking ratio,systolic blood pressure (SBP),low-density lipoprotein cholesterol (LDH-C),uric acid(UA),creatinine (Cr) and UACR in LEAD group were significantly higher than those in NLEAD group,while estimated glomerular filtration rate was significantly lower than that in NLEAD group (P<0.05).Diastolic blood pressure (DBP)、body mass index (BMI),glycosylated hemoglobin A1c (HbA1c)、fasting plasma glucose (FPG),total cholesterol (TC),total triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) had no significant difference between the two groups (P>0.05).Correlation analysis showed that UACR was positively correlated with age,course,SBP,HbA1c,Cr and UA,and negatively correlated with eGFR and ABI.Logistic regression analysis showed that SBP,LDL-C and UACR were risk factors T2DM combined with lower limb vascular lesions.Conclusion Increased UACR in patients with type 2 diabetes mellitus suggests a higher risk of LEAD,and regular monitoring of UACR is helpful for early prevention of LAED.
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