文章摘要
张媛媛,李玲,倪英群,李居一,张进军,刘怀珍.甲状腺功能正常的2型糖尿病患者游离三碘甲状腺原氨酸水平与白蛋白尿的相关性[J].中国临床保健杂志,2020,23(2):216-219.
甲状腺功能正常的2型糖尿病患者游离三碘甲状腺原氨酸水平与白蛋白尿的相关性
Connection between free triiodothyronine levels and albuminuria in type 2 diabetes mellitus patients with normal thyroid function
投稿时间:2020-02-10  
DOI:10.3969/J.issn.1672-6790.2020.02.019
中文关键词: 糖尿病,2型  三碘甲状腺原氨酸  白蛋白尿
英文关键词: Diabetes mellitus,type 2  Triiodothyronine  Albuminuria 〖FL
基金项目:安徽省自然科学基金项目(1908085MH267);安徽省中医药领军人才建设项目;安徽中医药大学自然重点项目(2018zrzd13)
作者单位E-mail
张媛媛 安徽中医药大学第一附属医院老年病中心内分泌科,合肥 230031 328283653@qq.com 
李玲 安徽中医药大学第一附属医院老年病中心内分泌科,合肥 230031  
倪英群 安徽中医药大学第一附属医院内分泌科,合肥 230031  
李居一 安徽中医药大学第一附属医院老年病中心内分泌科,合肥 230031  
张进军 安徽中医药大学第一附属医院老年病中心内分泌科,合肥 230031  
刘怀珍 安徽中医药大学第一附属医院老年病中心内分泌科,合肥 230031 640347226@qq.com 
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中文摘要:
      目的 探搜在甲状腺激素检测正常范围内的2型糖尿病(T2DM)患者中游离三碘甲状腺原氨酸(FT3)值与白蛋白尿的关联性。方法 搜集安徽中医药大学第一附属医院收治的166例T2DM患者病历资料,按照尿白蛋白/肌酐比≥30 mg/g定义为白蛋白尿,所有患者分成白蛋白尿组55例,非白蛋白尿组111例,分析两组患者一般资料,同时采用logistic回归剖析FT3与白蛋白尿之间的关联性。结果 白蛋白尿的检出率为33%。与非白蛋白尿组相比,白蛋白组中年龄、糖尿病病程、治疗年限、收缩压、腰围、臀围、肌酐、尿酸、空腹血糖、超氧化物歧化酶、FT3均有显著差异(P<0.05)。logistic回归剖析显示: FT3与白蛋白尿患病危险呈负相关,未纠正任何因素时P值为0.026,而纠正性别、年龄、病程、超氧化物歧化酶等混杂因素后P值为0.027。结论 FT3值下降是白蛋白尿患病的独立风险要素,尤其是在甲状腺激素检测非异常的T2DM人群中。
英文摘要:
      Objective To explore the connection between the value of free triiodothyronine (FT3) and albuminuria in type 2 diabetes mellitus(T2DM) patients within the normal range of thyroid hormone detection.Methods 166 T2DM patients who were received and cured to our hospital were gathered.In terms of urinary albumin/creatinine ratio ≥30 mg/g,albuminuria was defined.All patients were spanided into albuminuria group (55 cases) and non-albuminuria group (111 cases).Physical data of two groups of patients were analyzed,at the same time,logistic regression was used to analyze the relevance between FT3 and albuminuria.Results The detection rate of albuminuria was 33%.Age,systolic blood pressure,duration of diabetes,curative time,waistline,hipline,fasting blood glucose,superoxide dismutase,creatinine,unic acid and FT3 in albumin uria group were significantly different compared with non-albuminuria group(P<0.05).Logistic regression analysis demonstrated that FT3 was negatively correlated with the risk of albuminuria.The P value was 0.026 when no factors were corrected,while 0.027 after correcting the confounding factors such as sex,age,duration of diabetes,superoxide dismutase,etc.Conclusion The decrease of FT3 value is an independent risk factor for albuminuria,especially in T2DM population with normal thyroid hormone detection.
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