文章摘要
黄毕林,丁西平,单培彦,胡世莲.肠道微生物与老年人认知功能障碍[J].中国临床保健杂志,2020,23(2):174-177.
肠道微生物与老年人认知功能障碍
Intestinal microbes and cognitive dysfunction in the elderly
投稿时间:2019-07-20  
DOI:10.3969/J.issn.1672-6790.2020.02.008
中文关键词: 认知功能障碍  胃肠道微生物组  老年人  综述
英文关键词: Cognitive dysfunction  Gastrointestinal Microbiome  Aged  Review 〖FL
基金项目:安徽省科技计划项目(1501041142)
作者单位E-mail
黄毕林 中国科学技术大学附属第一医院安徽省立医院老年医学科五病区,合肥 230001
安徽省老年医学研究所
肿瘤免疫与营养治疗安徽省重点实验室 
dingxipingyx@163.com 
丁西平 中国科学技术大学附属第一医院安徽省立医院老年医学科五病区,合肥 230001 dingxipingyx@163.com 
单培彦 山东大学齐鲁医院老年神经内科 dingxipingyx@163.com 
胡世莲 安徽省老年医学研究所
肿瘤免疫与营养治疗安徽省重点实验室 
dingxipingyx@163.com 
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中文摘要:
      肠道微生物参与人体众多生理代谢活动,具有十分重要的生理意义,肠道微生物的组成与人体的健康状况密切相关。以往认为,由于血脑屏障和肠道屏障的存在,肠道微生物对大脑的影响很小。近年来越来越多的研究显示,肠道微生物可通过多种途径作用于中枢神经系统。不仅影响神经系统的正常发育,还参与了许多神经精神疾病的发病过程,如焦虑、抑郁症、孤独症、精神分裂症等,通过给患者服用益生菌等微生态制剂可改善患者的临床症状;更重要的进展提示,肠道微生物与认知障碍可能有重要关系。本文就肠道微生物和人体中枢神经系统之间的相互作用、肠道菌群在老年期的变化,以及肠道微生物在认知障碍中的作用和相关治疗进展做一综述。
英文摘要:
      Intestinal microbes participate in many physiological metabolic activities of the human body and have important physiological significance.The composition of intestinal microbes is closely related to the health status of the human body.It has been thought in the past that intestinal microbes have little effect on the brain due to the presence of the blood-brain barrier and the intestinal barrier.In recent years,more and more studies have shown that intestinal microbes can act on the central nervous system in a variety of ways.It not only affects the normal development of the nervous system,but also participates in the pathogenesis of many neuropsychiatric diseases,such as anxiety,depression,autism,schizophrenia,etc.The clinical symptoms of patients can be improved by administering micro-ecological preparations such as probiotics;some studies suggest that gut microbes may have an important relationship with cognitive impairment.Here we review the interactions between intestinal microbes and the central nervous system of the human body,changes in the intestinal flora in old age and the role of intestinal microbes in cognitive disorders and related treatment advances.
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