文章摘要
叶智勇,郑夏妹,郑尚荣,蒋辉,王松,杨文杰,谢敏超,吕敏.阿司匹林肠溶片联合他汀类药物治疗冠心病心绞痛的效果[J].中国临床保健杂志,2019,22(6):842-845.
阿司匹林肠溶片联合他汀类药物治疗冠心病心绞痛的效果
Efficacy of aspirin enteric-coated tablets combined with statins in the treatment of angina pectoris
投稿时间:2019-08-11  
DOI:10.3969/J.issn.1672-6790.2019.06.032
中文关键词: 冠心病  心绞痛  阿司匹林  羟甲基戊二酰基CoA还原酶抑制剂
英文关键词: Coronary disease  Angina pectoris  Aspirin  Hydroxymethylglutaryl-CoA reductase inhibitors〖FL
基金项目:安徽省重点研究与开发项目(1804h08020253)
作者单位E-mail
叶智勇 浙江台州市三门君同骨伤医院浙江省台州市博爱医院三门分院内科,317500 2268635366@qq.com 
郑夏妹 浙江台州市三门君同骨伤医院浙江省台州市博爱医院三门分院内科,317500  
郑尚荣 浙江台州市三门君同骨伤医院浙江省台州市博爱医院三门分院内科,317500  
蒋辉 浙江台州市博爱医院心内科  
王松 浙江台州市博爱医院心内科  
杨文杰 浙江台州市三门君同骨伤医院浙江省台州市博爱医院三门分院内科,317500  
谢敏超 浙江台州市三门君同骨伤医院浙江省台州市博爱医院三门分院内科,317500  
吕敏 浙江台州市三门君同骨伤医院浙江省台州市博爱医院三门分院内科,317500  
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中文摘要:
      目的 观察阿司匹林肠溶片联合他汀类药物治疗冠心病心绞痛患者的疗效,以为临床提供数据支持。方法 选出100例冠心病心绞痛患者,按照随机数字表法纳入对照组(n=50)及观察组(n=50),分别在常规治疗的基础上给予阿司匹林肠溶片治疗及阿司匹林肠溶片联合他汀类药物治疗,对比两组的临床疗效、止痛效果、硝酸甘油停减情况、心绞痛发作情况(发作次数、疼痛程度评分及持续时间)、心功能(左室舒张末期内径、左室收缩末期内径、左室射血分数)、生活质量(SF-36评分)。结果 观察组临床疗效的总有效率(94.0%)高于对照组(78.0%),观察组止痛效果的总有效率(90.0%)高于对照组(74.0%),观察组硝酸甘油停减率(98.0%)高于对照组(86.0%),观察组心绞痛发作次数、疼痛程度评分、持续时间均少于对照组,观察组治疗后的心功能指标均优于对照组,观察组治疗后的SF-36评分高于对照组,各组对比差异均显著(P<0.05)。结论 阿司匹林肠溶片联合他汀类药物治疗冠心病心绞痛患者的疗效显著,可提高硝酸甘油停减率,减少心绞痛发作次数与持续时间,减轻疼痛程度,还可改善心功能与生活质量,值得推行。
英文摘要:
      Objective To observe the effect of aspirin enteric-coated tablets combined with statins in the treatment of angina pectoris patients with coronary heart disease (CHD).Methods 100 patients with angina pectoris of coronary heart disease were randomly divided into control group (n=50) and observation group (n=50).On the basis of routine treatment,aspirin enteric-coated tablets and aspirin enteric-coated tablets combined with statins were given respectively.The clinical efficacy,analgesic effect,nitroglycerin withdrawal and heart rate of the two groups were compared.The incidence of angina pectoris (attack times,pain score and duration),cardiac function (left ventricular end diastolic diameter,left ventricular end systolic diameter,left ventricular ejection fraction),quality of life (SF-36 score). Results The total effective rate of the observation group (94.0%) was higher than that of the control group (78.0%).The total effective rate of the observation group (90.0%) was higher than that of the control group (74.0%).The stop-and-decrease rate of nitroglycerin in the observation group (98.0%) was higher than that in the control group (86.0%).The number of angina attacks,the pain score and the duration of the observation group were higher than those in the control group (86.0%).After treatment,the indexes of cardiac function in the observation group were better than those in the control group,and the SF-36 evaluation in the observation group was higher than that in the control group with significant differences among the groups (P<0.05).Conclusion Aspirin enteric-coated tablets combined with statins are effective in the treatment of angina pectoris patients with coronary heart disease.It can increase the stop-and-drop rate of nitroglycerin,reduce the frequency and duration of angina pectoris attacks,relieve pain,and improve heart function and quality of life.
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