文章摘要
李星,潘春联,程伟,王希佳,潘小梅.抗氧化疗法对脑梗死急性期合并糖尿病患者血管内皮功能及自主活动能力的影响[J].中国临床保健杂志,2019,22(6):770-774.
抗氧化疗法对脑梗死急性期合并糖尿病患者血管内皮功能及自主活动能力的影响
The effect of antioxidant therapy on vascular endothelial function and autonomous activity in patients with acute cerebral infarction complicated with diabetes mellitus
投稿时间:2019-04-27  
DOI:10.3969/J.issn.1672-6790.2019.06.013
中文关键词: 糖尿病,2型  脑梗死  硫辛酸  内皮,血管  抗氧化剂
英文关键词: Diabetes mellitus,type 2  Brain infarction  Thioctic acid  Endothelium,vascular  Antioxidants 〖FL
基金项目:湖北省武汉市卫生计生委医疗卫生科研项目(WX15D04)
作者单位E-mail
李星 湖北武汉市普仁医院神经内科,430081 38380545@qq.com 
潘春联 湖北武汉市普仁医院神经内科,430081  
程伟 湖北武汉市普仁医院神经内科,430081  
王希佳 湖北武汉市普仁医院神经内科,430081  
潘小梅 湖北武汉市普仁医院神经内科,430081  
摘要点击次数: 96
全文下载次数: 91
中文摘要:
      目的 探讨抗氧化疗法对脑梗死急性期合并糖尿病患者血管内皮功能及自主活动能力的影响。方法 按照随机数字表将160例脑梗死急性期合并糖尿病患者分成两组,每组80例。对照组按照常规治疗方法,观察组按照常规治疗方法同时联合抗氧化疗法(给予α-硫辛酸注射液,1次/天,2周为1个疗程)。治疗后,比较两组美国国立卫生研究院卒中量表(NIHSS)评分、氧化应激水平、血管内皮功能、不良反应;随访3个月,以改良Rankin量表(mRS)评估独立生活能力,采用改良Barthel指数(MBI)评定日常生活能力。结果 治疗后,观察组NHISS评分与入院时比较明显降低(P<0.05),且低于对照组NHISS评分(P<0.05);治疗2周后,观察组8-羟基脱氧鸟苷酸(8-OHDG)、丙二醛 (MDA)水平下降,低于对照组(P<0.05),超氧化物歧化酶(SOD)水平升高,高于对照组(P<0.05);两组内皮素-1(ET-1)、血栓素B-2(TXB2)水平降低,且观察组低于对照组(P<0.05),6-酮-前列腺素F1α(6-keto-PGF1α)、一氧化氮(NO)水平升高,且观察组高于对照组(P<0.05);两组均未发生明显不良反应,观察组患者未出现因不良反应而停药者;治疗后,两组Rankin 评分较治疗前降低(P<0.05),观察组Rankin 评分低于对照组(P<0.05),观察组MBI评分明显高于对照组(P<0.05)。结论 抗氧化疗法可有效改善脑梗死急性期合并糖尿病患者神经功能缺失程度,改善自主活动能力,且具有安全性,其机制可能与改善患者的血管内皮功能,抑制氧化应激水平有关。
英文摘要:
      Objective To investigate the effect of antioxidant therapy on endothelial function and autonomous activity in patients with acute cerebral infarction complicated with diabetes mellitus.Methods According to the random number table,160 patients with acute cerebral infarction complicated with diabetes were randomly divided into two groups,80 cases in each group.The control group was treated with routine therapy.The observation group was treated with alpha-lipoic acid injection once a day for 2 weeks combined with antioxidant therapy.After treatment,NIHSS score,oxidative stress level,vascular endothelial function and adverse reactions were compared between the two groups.After 3 months of follow-up,independent living ability was assessed by modified Rankin scale (mRS) and daily living ability was assessed by modified Barthel index (MBI).Results After 2 weeks of treatment,the NHISS score of the observation group was significantly lower than that of the control group (P<0.05),and the NHISS score of the observation group was significantly lower than that of the control group (P<0.05),and the levels of ET-1 and TXB2 in the two groups decreased,and the levels of 6-keto-PGF1 alpha in the observation group were lower than those in the control group (P<0.05),and the levels of 6-keto-PGF1 alpha in the observation group were lower than those in the control group (P<0.05).After the treatment,the levels of NO and NO in the observation group were higher than those in the control group (P<0.05).There were no obvious adverse reactions in the two groups,and no patients in the observation group stopped taking drugs because of adverse reactions.After the treatment,Rankin score in the two groups was lower than that before treatment (P<0.05),Rankin score in the observation group was lower than that in the control group (P<0.05),and MBI score in the observation group was significantly higher than that in the control group (P<0.05).Conclusion Antioxidant therapy can effectively improve the degree of neurological deficit and autonomic activity in patients with acute cerebral infarction complicated with diabetes mellitus with good safety.
查看全文     下载PDF阅读器
关闭
分享按钮