文章摘要
陈伟伟,王玉芬,车琦.短期胰岛素强化治疗对初诊老年2型糖尿病患者胰岛β细胞功能的影响[J].中国临床保健杂志,2019,22(6):763-765.
短期胰岛素强化治疗对初诊老年2型糖尿病患者胰岛β细胞功能的影响
The effect of short-term intensive isulin therapy on islet β cell function and blood glucose in newly diagnosed elderly patients with type 2 diabetes
投稿时间:2019-01-12  
DOI:10.3969/J.issn.1672-6790.2019.06.011
中文关键词: 糖尿病,2型  胰岛素  胰岛素分泌细胞  低血糖症  老年人
英文关键词: Diabetes mellitus,type 2  Insulin  Insulin-secreting cells  Hypoglycemia  Aged 〖FL
基金项目:安徽省科技攻关计划项目(1604a0802074)
作者单位E-mail
陈伟伟 中国人民解放军总医院第三医学中心原首保临床部,北京 100039 wangshihan012@sina.com 
王玉芬 中国人民解放军总医院第三医学中心原首保临床部,北京 100039  
车琦 中国人民解放军总医院第三医学中心原首保临床部,北京 100039  
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中文摘要:
      目的 探讨短期胰岛素强化治疗对初诊老年2型糖尿病患者胰岛β细胞功能及血糖的影响。方法 将80例新诊断的老年2型糖尿病患者,按随机数字表法分成胰岛素强化治疗组(A组)和口服药物治疗组(B组)。比较两组治疗前后空腹血糖(FPG),馒头餐2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FIns)、空腹C肽(FCP)、β细胞胰岛素分泌指数(HOMA-IS)、β细胞胰岛素抵抗指数(HOMA-IR)等指标。结果 两组治疗后FPG、2 hPG、HOMA-IR较治疗前降低(P<0.05),空腹胰岛素、空腹C肽、HOMA-IS较治疗前升高(P<0.05);治疗后两组间比较,A组空腹胰岛素、HOMA-IS增高较B组明显(P<0.05),B组HOMA-IR降低较A组明显(P<0.05),两组治疗过程中低血糖发生率差异无统计学意义(P>0.05)。结论 胰岛素强化治疗可更好地控制老年2型糖尿病患者的血糖水平,改善β细胞功能,不增加低血糖风险。
英文摘要:
      Objective To investigate the effect of short-term intensive insulin therapy on islet β cell function and blood glucose in newly diagnosed elderly patients with type 2 diabetes. Methods Eighty newly diagnosed elder patients with type 2 diabete smellitus were randomly assigned to two groups.Group A was given short-term intensive insulin treatment and group B was given oral hypoglycemic agents.The two groups were detected and analyzed with the Fasting plasma glucose (FPG),the plasma glucose level in 2 hours aftermeal (2 hPG),the HbA1c,the fastinginsulin(FIns),the fasting C-peptide (FCP),the homeostasis model assessment insulin secrete (HOMA-IS),the homeostasis model assessment for insulin resistance (HOMA-IR) and so on before and after treatment.Results After treatment,the levels of FPG,2 hPG,HOMA-IR in group A were decreased (P<0.05),while the levels of FIns,FCP,HOMA-IS increased obviously (P<0.05).The levels of the levels of FPG,2 hPG,HOMA-IR in group B were decreased (P<0.05),while the levels of FIns,FCP and HOMA-IS increased obviously (P<0.05).After treatment,the FIns and HOMA-IS of group A were increased significantly (P<0.05),while the HOMA-IR of group B showed a significant decrease compared with group B(P<0.05).There was no significant difference in the incidence of hypoglycemia between two groups (P>0.05).Conclusion The short-term intensive insulin treatment can improve the function of islet β cells of newly diagnosed elderly patients with type 2 diabetes mellitus without increasing the risk of hypoglycemia.
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