文章摘要
陈云江,龚艳春.卡维地洛治疗慢性心力衰竭的效果及对左心重构与B型尿钠肽和超敏肌钙蛋白T水平的影响[J].中国临床保健杂志,2019,22(6):749-752.
卡维地洛治疗慢性心力衰竭的效果及对左心重构与B型尿钠肽和超敏肌钙蛋白T水平的影响
Effects of carvedilol on left ventricular remodeling,BNP and Hs-cTnT levels in patients with chronic heart failure
投稿时间:2019-08-20  
DOI:10.3969/J.issn.1672-6790.2019.06.008
中文关键词: 心力衰竭  肾上腺素能β受体拮抗剂  心室重构  利钠肽,脑  肌钙蛋白T
英文关键词: Heart failure  Adrenergic beta-antagonists  Ventricular Remodeling  Natriuretic peptide,brain  Troponin T 〖FL
基金项目:2016年高校学科(专业)拔尖人才学术资助重点项目(gxbjZD2016036)
作者单位E-mail
陈云江 上海交通大学医学院附属瑞金医院全科医学科,上海 200025 gyc10543@rjh.com.cn 
龚艳春 上海交通大学医学院附属瑞金医院全科医学科,上海 200025 gyc10543@rjh.com.cn 
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中文摘要:
      目的 探究卡维地洛治疗慢性心力衰竭的临床效果,并分析其对左心重构、B型尿钠肽(BNP)和超敏肌钙蛋白T(hs-cTnT)水平的影响。方法 选取120例慢性心力衰竭(CHF)住院患者,按随机数字表法将其分为对照组(n=60)和观察组(n=60)。两组均给予常规药物治疗,对照组在常规药物治疗的基础上给予美托洛尔治疗,观察组常规药物治疗的基础上给予卡维地洛治疗,两组均连续治疗3个月。统计两组治疗后临床疗效;比较两组患者治疗前后左心重构指标,比较两组患者治疗前后BNP、hs-cTnT水平,统计并比较两组患者不良反应发生情况。结果 治疗后观察组临床总有效率为91.67%,对照组临床总有效率为75.00%。经比较,观察组临床总有效率显著高于对照组临床总有效率(P<0.05);与治疗前比,治疗后两组患者左心室舒张末内径、左心室收缩末容积及血清BNP、hs-cTnT显著下降,且观察组显著低于对照组(P<0.05或P<0.01);左室射血分数显著升高,且观察组显著高于对照组(P<0.05或P<0.01);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论 卡维地洛可有效提高CHF患者临床疗效,延缓左心重构,提高心功能,降低BNP、hs-cTnT水平,安全性良好。
英文摘要:
      Objective To explore the clinical effect of carvedilol in the treatment of CHF,and analyze the effect on left ventricular remodeling,BNP and hs-cTnT.Methods One hundred and twenty patients with CHF were selected and they were divided into control group and observation group according to the random number table method.Both groups were given conventional therapy,the control group was given metoprolol on the basis of conventional therapy,and the observation group was given carvedilol on the basis of conventional therapy,and both groups were treated continuously for 3 months.The left ventricular remodeling index,BNP and hs-cTnT in the two groups before and after treatment were compared;and the adverse reactions was compared in the two groups.Results After treatment,the total clinical effective rate was 91.67% in the observation group and 75.00% in the control group.The total clinical effective rate in the observation group was significantly higher than that in the control group (P<0.05).The LVEDD,LVESD,BNP and hs-cTnT in the two groups were significantly decreased after treatment,and the observation group was significantly lower than the control group (P<0.05 or P<0.01).The LVEF in the observation group was significantly higher than that in the control group (P<0.05 or P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Carvedilol can effectively improve the clinical efficacy of CHF patients,delay left ventricular remodeling,improve cardiac function,reduce BNP and hs-cTnT with good safety.
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