文章摘要
刘芳芳,刘自双,陈珊珊,张新峰,石汉品.胸腺五肽联合头孢哌酮钠舒巴坦钠对老年糖尿病并肺部感染的疗效及血清C反应蛋白和白细胞介素-6水平的影响[J].中国临床保健杂志,2019,22(5):601-603.
胸腺五肽联合头孢哌酮钠舒巴坦钠对老年糖尿病并肺部感染的疗效及血清C反应蛋白和白细胞介素-6水平的影响
Effect of thymopentin combined with cefoperazone sodium and sulbactam sodium in elderly patients with diabetes mellitus complicated with pulmonary infection and its effect on serum CRP and interleukin-6 levels
投稿时间:2018-08-21  
DOI:10.3969/J.issn.1672-6790.2019.05.007
中文关键词: 糖尿病  肺炎  免疫调节  抗菌药  C反应蛋白  白细胞介素6
英文关键词: Diabetes mellitus  Pneumonia  Immunomodulation  Anti-bacterial agents  C-reactive protein  Interleukin-6 〖FL
基金项目:国家重点研发计划项目(2017YFC1309200)
作者单位E-mail
刘芳芳 首都医科大学附属北京康复医院老年康复中心,北京 100144 appleyue2013@163.com 
刘自双 首都医科大学附属北京康复医院老年康复中心,北京 100144  
陈珊珊 首都医科大学附属北京康复医院老年康复中心,北京 100144  
张新峰 首都医科大学附属北京康复医院老年康复中心,北京 100144  
石汉品 中国医科大学航空总医院  
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中文摘要:
      目的 探讨胸腺五肽联合头孢哌酮钠舒巴坦钠对老年糖尿病合并肺部感染患者的疗效及对患者血清C反应蛋白(CRP)、白细胞介素-6(IL-6)水平的影响。 方法 86例老年糖尿病合并肺部感染患者按照随机数字表法分为研究组(胸腺五肽联合头孢哌酮钠舒巴坦钠治疗,43例)和对照组(单纯应用头孢哌酮钠舒巴坦钠治疗,43例)。比较两组患者治疗前后空腹血糖值、血清CRP、血清IL-6、临床疗效、不良反应发生率等指标的差异。 结果 研究组患者体温、肺部啰音恢复、肺部阴影吸收及咳嗽咳痰减轻所需时间均短于对照组(P均<0.05)。研究组临床治疗有效率为95.35%(41/43),对照组为81.40%(35/43),研究组高于对照组(P<0.05)。经治疗,两组患者的血清CRP、IL-6水平均低于治疗前(P均<0.05),且研究组低于对照组(P均<0.05)。研究组中,恶心呕吐1例,发生率为2.32%,对照组中,恶心呕吐3例、上腹不适2例、皮疹2例,发生率为16.28%,研究组低于对照组(P<0.05)。 结论 胸腺五肽联合头孢哌酮钠舒巴坦钠治疗老年糖尿病合并肺部感染,临床疗效优于单纯使用头孢哌酮钠舒巴坦,且不良反应少。
英文摘要:
      Objective To investigate the effect of thymopentin combined with cefoperazone sodium and sulbactam sodium on elderly patients with diabetes mellitus complicated with pulmonary infection and its effect on serum CRP and interleukin-6 levels. Methods Eighty-six elderly patients with diabetes mellitus complicated with pulmonary infection were enrolled,they were divided into study group (Thymosin combined with cefoperazone sodium and sulbactam sodium,43 cases) and control group (cefoperazone sodium and sulbactam sodium alone,43 cases) according to the random number table method,each group had 43 cases.The differences of fasting blood glucose,clinical efficacy,serum CRP,serum IL-6 and adverse reaction rate before and after treatment were compared between the two groups. ResultsThe time required for body temperature,lung acuity recovery,lung shadow absorption and cough and cough reduction in the study group were shorter than those in the control group (all P<0.05).The effective rate of clinical treatment in the study group was 95.35% (41/43) and control group was 81.40% (35/43),the study group was higher than the control group (P<0.05).After treatment,the serum levels of CRP and IL-6 in the two groups were lower than those before treatment (P<0.05).The study group was lower than the control group (P<0.05).There was 1 case of nausea and vomiting in the study group and the incidence of complications was 2.32%.In the control group,there were 3 cases of nausea and vomiting,2 cases of upper abdominal discomfort and 2 cases of rash,and the incidence of complications was 16.28%(P<0.05). Conclusion In the treatment of elderly patients with diabetes mellitus complicated with pulmonary infection,thymopentin combined with cefoperazone sodium and sulbactam sodium is better than that of either cefoperazone sodium or sulbactam alone with less adverse reaction.
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