文章摘要
朱琦,谢琛红,郭红,张超男,丁卓颖.阿立哌唑联合多奈哌齐治疗阿尔茨海默病的效果及对认知及行为能力的影响[J].中国临床保健杂志,2019,22(4):552-555.
阿立哌唑联合多奈哌齐治疗阿尔茨海默病的效果及对认知及行为能力的影响
Therapeutic effect of aripiprazole combined with donepezil on Alzheimer′s disease and its influence on cognitive and behavioral ability
投稿时间:2019-04-07  
DOI:10.3969/J.issn.1672-6790.2019.04.032
中文关键词: 阿尔茨海默病  阿立哌唑  多奈哌齐  认知  日常生活活动
英文关键词: Alzheimer disease  Aripiprazole  Donepezil  Cognition  Activities of daily living 〖FL
基金项目:
作者单位E-mail
朱琦 浙江绍兴市第七人民医院神经内科, 312000 448994784@qq.com 
谢琛红 浙江绍兴市第七人民医院老年二科, 312000  
郭红 浙江绍兴市第七人民医院精神二科, 312000  
张超男 浙江绍兴市第七人民医院神经内科, 312000  
丁卓颖 浙江绍兴市第七人民医院门急诊, 312000  
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中文摘要:
      目的 探讨阿立哌唑联合多奈哌齐治疗阿尔茨海默病的效果及对认知及行为能力的影响。方法选取100例阿尔茨海默病患者按照随机数字表法纳入对照组(50例)与观察组(50例),分别予以多奈哌齐与阿立哌唑+多奈哌齐治疗,对比两组患者的症状评分[痴呆行为量表(BEHAVE-AD)]、临床疗效、认知功能[简易智能状态量表(MMSE)]、行为能力[日常生活能力量表(ADL)]。结果 治疗后观察组的BEHAVE-AD评分[(7.8±1.4)分]低于对照组[(9.6±1.7)分],观察组总有效率(94.0%)高于对照组(80.0%),治疗后观察组的MMSE评分[(22.0±3.4)分]高于对照组[(17.6±3.7)分],治疗后观察组的ADL评分[(33.2±3.5)分]低于对照组[(36.5±3.9)分],各组差异均有统计学意义(P<0.05)。结论 阿立哌唑联合多奈哌齐治疗阿尔茨海默病疗效满意,可明显减轻患者的临床症状,提高其认知功能与行为能力。
英文摘要:
      Objective To analyze the efficacy of aripiprazole combined with donepezil in the treatment of Alzheimer′s disease and its influence on cognitive and behavioral ability,and to explore the better clinical treatment for the disease.Methods 100 patients with Alzheimer′s disease were randomly divided into the control group (50 cases) and the observation group (50 cases).They were treated with donepezil and aripiprazole combined with donepezil respectively.The symptoms score (BEHAVE-AD),clinical efficacy,cognitive function (MMSE) and behavior of the two groups were compared.Ability (ADL).Results After treatment,the BEHAVE-AD score of the observation group [(7.8±1.4)points] was lower than that of the control group [(9.6±1.7 )points],the total effective rate of the observation group (94.0%) was higher than that of the control group (80.0%),the MSE score of the observation group [(22.0±3.4)points] was higher than that of the control group [(17.6±3.7)points],and the ADL score of the observation group [(33.2±3.5)points] was lower than that of the control group [(36.5±3.9)points],and the differences among the groups were all.Significant(P<0.05).Conclusions Aripiprazole combined with donepezil is effective in the treatment of Alzheimer′s disease.It can obviously relieve the clinical symptoms and improve the cognitive and behavioral abilities of patients.
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