文章摘要
李烨,胡世莲,袁庆婷,方向,丁西平.老年慢性病患者铁代谢异常与慢性病的相关性[J].中国临床保健杂志,2019,22(4):459-463.
老年慢性病患者铁代谢异常与慢性病的相关性
Analysis of abnormal iron metabolism in the elderly pepole with chronic diseases
投稿时间:2019-03-10  
DOI:10.3969/J.issn.1672-6790.2019.04.008
中文关键词: 慢性病  血清铁蛋白  铁缺乏  铁过载  老年
英文关键词: Chronic disease  Serum ferritin  Iron deficiency  Iron overload  Elderly people 〖FL
基金项目:中央引导地方科技发展专项专业性技术创新平台项目(2017070503B041,YDZX20183400002555);安徽省科技攻关项目(1501041142)
作者单位E-mail
李烨 中国科学技术大学附属第一医院安徽省立医院老年医学科,合肥 230001
安徽省老年医学研究所
肿瘤免疫与营养治疗安徽省重点实验室] 
yale-lee@163.com 
胡世莲 中国科学技术大学附属第一医院安徽省立医院老年医学科,合肥 230001
安徽省老年医学研究所
肿瘤免疫与营养治疗安徽省重点实验室] 
 
袁庆婷 中国科学技术大学附属第一医院安徽省立医院老年医学科,合肥 230001  
方向 中国科学技术大学附属第一医院安徽省立医院老年医学科,合肥 230001
安徽省老年医学研究所
肿瘤免疫与营养治疗安徽省重点实验室] 
 
丁西平 中国科学技术大学附属第一医院安徽省立医院老年医学科,合肥 230001 dingxipingyx@163.com 
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中文摘要:
      目的 调查老年慢性病患者中铁代谢紊乱情况,为临床针对性补铁提供依据。方法 检测1 555位参与者血清铁蛋白浓度,并分为高血压病组、2型糖尿病组、冠心病组、心力衰竭组、脑梗死组及对照组,并对比各疾病组、各年龄段、性别组的血清铁蛋白含量差异。结果 血清铁蛋白含量为157.60(87.65,7.21)μg/L,男性为167.00(92.97,5.20)μg/L,女性为145.14(79.99,4.50)μg/L;铁缺乏率为7.52%,过载率为28.94%;男女性铁缺乏率分别为9.96%、4.24%,过载率为14.77%、48.11%;各慢性病组的铁超载均较对照组有差异(P<0.05),冠心病组、心力衰竭组铁缺乏较对照组差异有统计学意义(P<0.05);血清铁蛋白浓度低对男性心力衰竭、血清铁蛋白浓度高对女性高血压具有较好的诊断价值。结论 老年高血压病、2型糖尿病、冠心病、心力衰竭、脑梗死患者铁超载普遍,血清铁蛋白浓度对慢性病评估具有临床价值。
英文摘要:
      Objective To investigate the disorder of iron metabolism in elderly patients with chronic diseases,and to provide evidence for clinical targeted iron supplementation.Methods The serum ferritin concentrations of 1 555 participants were measured,and divided into hypertension group,type 2 diabetes group,coronary heart disease group,heart failure group,cerebral infarction group and control group.They were compared that differences and similarities of serum ferritin contents in each disease group,age group,gender group.Results The total serum ferritin content of all subjects was 157.60(87.65,7.21)μg/L,167.00(92.97,5.20)μg/L for males and 145.14(79.99,254.50)μg/L for females.The iron deficiency rate was 7.52% and the overload rate was 28.94%.The iron deficiency rates were 9.96%,4.24%,overload rates were 14.77% and 48.11%,respectively.Iron overload in the chronic disease group was significantly different from that in the control group (P<0.05),and iron deficiency in the coronary heart disease group and heart failure group was significantly different from that in the control group (P<0.05).Low serum ferritin concentration has moderate diagnostic value for male heart failure and high serum ferritin concentration for female hypertension.Conclusion Iron overload is common in elderly patients with hypertension,type 2 diabetes,coronary heart disease,heart failure and cerebral infarction.Serum ferritin concentration is valuable for the evaluation of chronic diseases.
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