文章摘要
于海娜,刘永丹,李艳华.脑梗死患者血清可溶性细胞间粘附分子-1、信号传导及转录激活子-4和肿瘤坏死因子-α水平及临床意义[J].中国临床保健杂志,2019,22(2):196-199.
脑梗死患者血清可溶性细胞间粘附分子-1、信号传导及转录激活子-4和肿瘤坏死因子-α水平及临床意义
The clinical significance of serum sICAM-1,STAT-4 and TNF-α detection in patients with cerebral infarction
投稿时间:2019-02-22  
DOI:10.3969/J.issn.1672-6790.2019.02.014
中文关键词: 脑梗死  可溶性细胞间粘附分子-1  信号传导及转录激活子-4  肿瘤坏死因子α  危险因素
英文关键词: Brain infarction  Soluble intercellular adhesion molecule-1  Signal transduction and transcription activator-4  Tumor necrosis factor-alpha  Risk factors 〖FL
基金项目:黑龙江省科学基金项目计划任务书(QC2015122)
作者单位E-mail
于海娜 辽宁朝阳市中心医院,全科医学科,122000 hirra@163.com 
刘永丹 黑龙江省医院神经内科  
李艳华 辽宁朝阳市中心医院 门诊部,122000  
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中文摘要:
      目的 探讨脑梗死患者血清可溶性细胞间粘附分子-1(sICAM-1)、信号传导及转录激活子-4(STAT-4)、肿瘤坏死因子-α(TNF-α)水平及临床意义。方法 选取在我院治疗的脑梗死患者105例(病例组),同时选取健康志愿者100例作为对照组,检测各受试者血清sICAM-1、STAT-4、TNF-α水平。结果 病例组血清sICAM-1、STAT-4和TNF-α分别为(273.75±37.32)μg/L、(218.25±45.55)ng/L和(14.11±2.01)pg/mL,明显高于对照组(p<0.05);不同梗死灶体检患者血清sICAM-1、STAT-4和TNF-α差异有统计学意义(P<0.05),其中大梗死灶患者血清sICAM-1、STAT-4和TNF-α分别为(320.02±28.89)μg/L、(260.83±28.78)ng/L和(19.82±3.11)pg/mL,明显高于小梗死灶和中梗死灶(P<0.05);不同神经功能缺损患者血清sICAM-1、STAT-4和TNF-α差异有统计学意义(P<0.05),其中神经功能高度缺损患者血清sICAM-1、STAT-4和TNF-α分别为(317.50±34.55)μg/L、(257.71±29.50)ng/L和(19.02±3.04)pg/mL,明显高于轻度缺损和中度缺损患者(P<0.05);梗死灶体积与血清sICAM-1、STAT-4和TNF-α呈正相关(r=0.356、0.361和0.334,P<0.05);NIHSS评分与血清sICAM-1、STAT-4和TNF-α呈正相关(r=0.487、0.453和0.412,P<0.05)。结论 脑梗死患者sICAM-1、STAT-4、TNF-α水平明显升高,与梗死灶体积及神经功能缺损严重程度有关。
英文摘要:
      Objective To investigate the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1),signal transduction and transcription activator-4 (STAT-4) and tumor necrosis factor-α (TNF-α) in patients with cerebral infarction and their clinical significance.Methods 105 patients (case group) with cerebral infarction treated in our hospital were selected,100 healthy volunteers were selected as control group,serum levels of sICAM-1,STAT-4 and TNF-α were measured.Results The serum levels of sICAM-1,STAT-4 and TNF-α in the case group were (273.75±37.32) μg/L,(218.25±45.55) ng/L and (14.11±2.01) pg/mL,which were significantly higher than those in the control group (P<0.05);There were significant differences in serum sICAM-1,STAT-4 and TNF-α among patients with different infarction lesions (P<0.05),serum sICAM-1,STAT-4 and TNF-α in patients with large infarction were (320.02±28.89) μg/L,(260.83±28.78) ng/L and (19.82±3.11) pg/mL,which were significantly higher than those in patients with small infarction and middle infarction (P<0.05);There were significant differences in serum sICAM-1,STAT-4 and TNF-α among patients with different neurological deficits (P<0.05),serum sICAM-1,STAT-4 and TNF-α in patients with high neurological deficits were (317.50±34.55) μg/L,(257.71±29.50) ng/L and (19.02±3.04) pg/mL,which were significantly higher than those in patients with mild and moderate neurological deficits(P<0.05);The infarct volume were positively correlated with serum sICAM-1,STAT-4 and TNF-α (r=0.356,0.361,0.334,P<0.05);NIHSS score were positively correlated with serum sICAM-1,STAT-4 and TNF-α (r=0.487,0.453,0.412,P<0.05).Conclusion The levels of sICAM-1,STAT-4,and TNF-α in patients with cerebral infarction were significantly increased,which were related to the volume of infarct size and the severity of neurological deficit.
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