文章摘要
董艳娟,蔡晓平,刘莹,刘丹,贺昕.尿液神经丝蛋白检测对老年阿尔茨海默病患者的临床意义[J].中国临床保健杂志,2019,22(2):179-181.
尿液神经丝蛋白检测对老年阿尔茨海默病患者的临床意义
Clinical significance of urinary AD7c-NTP detection in elderly patients with Alzheimer′s disease
投稿时间:2018-09-18  
DOI:10.3969/J.issn.1672-6790.2019.02.009
中文关键词: 阿尔茨海默病  神经微丝蛋白质类,尿  诊断技术和方法
英文关键词: Alzheimer disease  Neurofilament proteins,urine  Diagnostic techniques and procedures 〖FL
基金项目:军队后勤科研面上项目(CWS11J099)
作者单位E-mail
董艳娟 中国人民解放军总医院第七医学中心干部病房三科,北京 100700 dyj1219@163.com 
蔡晓平 中国人民解放军总医院第七医学中心干部病房三科,北京 100700  
刘莹 中国人民解放军总医院第七医学中心干部病房三科,北京 100700  
刘丹 中国人民解放军总医院第七医学中心干部病房三科,北京 100700  
贺昕 中国人民解放军总医院第七医学中心干部病房三科,北京 100700  
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中文摘要:
      目的 探讨老年阿尔茨海默病(AD)患者尿液中神经丝蛋白含量检测的临床意义。 方法 AD组:门诊以及住院诊断为AD患者66例(AD组),其中男性60例,女性6例;年龄范围75~96岁,年龄(87.27±4.95)岁;对照组:智能正常老人85名,其中男性72名,女性13名;年龄范围74~98岁,年龄(86.93±5.21)岁,所有受试者进行认知功能测评,包括简易智能状态检查量表(MMSE)、临床痴呆评定量表(CDR),Hachinski缺血指数量表(HIS)。根据量表评分将AD组分为轻、中、重组。采集尿液标本进行尿液中神经丝蛋白(AD7c-NTP)含量检测。 结果(1)AD组尿AD7c-NTP阳性明显高于对照组,两组阳性率比较,差异有统计学意义(P<0.001);(2)两组受试者年龄、性别、教育背景与AD7c-NTP含量的相关性分析(Pearson相关分析)显示,两组尿AD7c-NTP含量与以上诸因素均无明显相关性;MMSE分数与AD7c-NTP含量呈负相关,CDR分数与AD7c-NTP含量呈正相关。(3)轻度AD组与中、重度AD组尿AD7c-NTP含量比较差异有统计学意义(F=88.756,P<0.001),提示尿中的AD7c-NTP含量随疾病严重程度增加而上升。 结论 通过对老年AD患者尿液中AD7c-NTP含量检测,可以对AD的诊断提供帮助,并可能与病情严重程度有一定的关系。
英文摘要:
      Objective To investigate the clinical value of the of neuronal thread protein (AD7c-NTP) in urine of elderly patients with Alzheimer′s disease. Methods AD group:Outpatients and hospitalized patients were diagnosed as AD patients 66 cases (AD group),including 60 males and 6 females;aged 75 to 96 years,mean age (87.27±4.95) years old;control group:normal elderly 85 Names,including 72 males and 13 females;ages 74 to 98 years,mean age (86.93±5.21) years,all participants assessed cognitive function assessment,including Mini-Mental State Examination (MMSE),clinical dementia Scale (CDR),Hachinski Ischemic Index (HIS).According to the scale score,the AD group was divided into mild,moderate,and severe.Urine samples were collected for urinary levels of AD7c-NTP. Results1.The positive rate of urinary AD7c-NTP in AD group was significantly higher than that in control group,P<0.001.2.The correlation analysis of age,sex,education background and AD7c-NTP content (Pearson correlation analysis) showed that there was no significant correlation between urinary AD7c-NTP and the above factors;MMSE score and urinary AD7c-NTP were negative correlatively,the CDR score was positively correlated with AD7c-NTP.3.The difference of urinary AD7c-NTP between mild and moderate AD group and severe AD group was statistically significant (F=88.756,P<0.001),suggesting that the urinary AD7c-NTP increased with the severity of the disease. Conclusion The detection of AD7c-NTP in the urine of elderly AD patients can help for clinical diagnosis and assessment of the severity of AD.
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