文章摘要
李国宏.艾司西酞普兰治疗缺血性脑卒中后抑郁的效果[J].中国临床保健杂志,2019,22(1):100-103.
艾司西酞普兰治疗缺血性脑卒中后抑郁的效果
Clinical observation of escitalopram on depression after ischemic stroke
投稿时间:2018-09-14  
DOI:10.3969/J.issn.1672-6790.2019.01.027
中文关键词: 卒中  抑郁  神经生长因子类  艾司西酞普兰
英文关键词: Stroke  Depression  Nerve growth factors  Escitalopram 〖FL
基金项目:
作者单位E-mail
李国宏 四川内江市中医医院药剂科,641000 r156475@163.com 
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中文摘要:
      目的 观察艾司西酞普兰治疗缺血性脑卒中伴抑郁的临床疗效及可能机制。 方法 90例患者按照随机数字表法分为对照组和观察组各45例,两组均予卒中常规治疗。对照组加服帕罗西汀,观察组加服艾司西酞普兰。12周为一疗程。治疗前、治疗6周和治疗12周分别采用采用美国国立卫生院卒中量表(NIHSS)、汉密尔顿抑郁量表(HAMD)和脑卒中专门化生存质量量表(SS-QOL)评价神经功能缺损、抑郁和生活质量,比较临床疗效;测定血清脑源性神经营养因子(BDNF)和胶质细胞源性神经营养因子(GDNF),记录不良反应。 结果治疗12周后,观察组抑郁痊愈率为42.2%,高于对照组22.2%;SS-QOL量表中情绪评分为(11.80±2.53)分,高于对照组(9.56±2.33)分;血清BDNF含量为(21.11±2.38)ng/ L,高于对照组的(18.24±2.12)ng/ L;观察组不良反应发生率为24.4%,明显低于对照组的77.8%(P<0.05)。其余指标组间相近(P>0.05)。 结论 艾司西酞普兰对缺血性脑卒中伴抑郁具有良好辅助治疗作用,其机制可能与提高血清BDNF有关。
英文摘要:
      Objective To observe the clinical effects of escitalopram in the treatment of depression after ischemic stroke and its mechanisms. Methods 90 cases with depression after ischemic stroke were randomly divided into control group (45 cases) and study group (45 cases).Besides conventional treatments for stroke,the control group received paroxetine additionally,the study group received escitalopram additionally.All treated for 12 weeks.Before treatment,6 weeks and 12 weeks after treatment,Hamilton Depression Scale (HAMD),the National Institutes of Health Stroke Scale (NIHSS),and stroke-specific quality of life scale (SS-QOL) were used to evaluate depression,neurologic deficit and quality of life scale.The clinical effects were compared.The serum level of brain-derived neurotrophic factor (BDNF) and Glial cell derived neurotrophic factor (GDNF) were measured,and the adverse reactions were evaluated by Treatment Emergent Side Effect Scale (TESS). Results After treatment of 12 weeks,the cure rate of depression was 42.2% in the study group,which was higher than that of control group of 22.2%.The emotion score in SS-QOL was (11.80±2.53),which was higher than that of control group of (9.56±2.33).The serum level of BDNF was (21.11±2.38) ng/ L,which was higher than that of control group of (18.24±2.12) ng/ L.The incidence of adverse reaction was 24.4%,which was lower than that of control group of 77.8% (P<0.05).The other indexes were similar between two groups (P>0.05). Conclusion Escitalopram shows good adjunctive effect for patients with depression after ischemic stroke,increasing serum level of BDNF may be its mechanism.
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