文章摘要
孟庆云,程娟,王凯,李淮玉.多系统萎缩患者自主神经功能障碍的临床研究[J].中国临床保健杂志,2019,22(1):82-85.
多系统萎缩患者自主神经功能障碍的临床研究
Clinical analysis of autonomic dysfunction in patients with multiple system atrophy
投稿时间:2018-07-15  
DOI:10.3969/J.issn.1672-6790.2019.01.022
中文关键词: 多系统萎缩  原发性自主神经功能障碍  低血压,直立性  排尿障碍
英文关键词: Multiple system atrophy  Primary dysautonomias  Hypotension,orthostatic  Urination disorders 〖FL
基金项目:安徽省科技厅科技计划项目(1301043014)
作者单位E-mail
孟庆云 安徽医科大学附属省立医院、安徽省立医院神经内科,合肥230001 lihy519@126.com 
程娟 安徽医科大学附属省立医院、安徽省立医院神经内科,合肥230001 lihy519@126.com 
王凯 安徽医科大学附属省立医院、安徽省立医院神经内科,合肥230001 lihy519@126.com 
李淮玉 安徽医科大学附属省立医院、安徽省立医院神经内科,合肥230001 lihy519@126.com 
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中文摘要:
      目的 探讨多系统萎缩(MSA)患者自主神经功能障碍的特点。方法 选取46例MSA患者,根据MSA分级诊断标准,分为很可能的MSA组27例,其中MSA-P亚型10例,MSA-C亚型17例。可能的MSA组19例,其中MSA-P亚型9例,MSA-C亚型10例。收集所有患者的临床资料,包括性别、年龄、首次发病症状、病程;本次住院时症状、体征和既往病史。所有患者均完成膀胱残余尿、卧立位血压检查。分析不同等级及不同亚型MSA患者的膀胱残余尿量、卧立位血压差异。结果 (1)很可能的MSA组患者中MSA-P亚型和MSA-C亚型之间膀胱残余尿量、卧立位血压下降差值,差异无统计学意义(P>0.05)。(2)可能的MSA组患者中MSA-P亚型和MSA-C亚型之间膀胱残余尿量、卧立位血压下降差值,差异无统计学意义(P>0.05)。结论 (1)MSA患者两种亚型间排尿功能障碍出现率及严重程度类似。(2)MSA患者两型间直立性低血压的发生情况类似,两种亚型间收缩压和舒张压下降程度无差异。
英文摘要:
      Objective To explore the characteristics and severity of autonomic dysfunction in patients with MSA by analysing postvoid residual volume and decline in blood pressure between possible MSA and probable MSA.Furthermore,to compare them between two subtypes of MSA. Methods According to the criteria of MSA classification,46 patients with multiple system atrophy were divided into probable MSA group (n=27) and possible MSA group(n=19).Probable MSA group (range from 43 to 77 years old) were further divided into MSA-P subtype(n=10) and MSA-C subtype(n=17).Possible MSA group (range from 49 to 76 years old) were further divided into MSA-P subtype(n=10) and MSA-C subtype(n=17).The clinical data of all the patients were collected,including gender,age,first onset symptoms,course of disease,signs and past medical history.All patients completed postvoid residual volume,supine orthostatic blood pressure examination. Results (1) There was no significant difference in bladder residual urine volume and decubitus blood pressure between MSA-P subtype and MSA-C subtype in probable MSA(P>0.05).(2) There was no significant difference in bladder residual urine volume and decubitus blood pressure between MSA-P subtype and MSA-C subtype in possible MSA(P>0.05). Conclusion (1) The incidence and severity of urethral dysfunction are similar between the two subtypes of MSA.(2)The incidence of orthostatic hypotension is similar in patients with MSA.There is no difference in drop of blood pressure between the two subtypes.
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