文章摘要
文建庭,刘健,忻凌,万磊,董文哲,方妍妍.基于数据挖掘的老年骨关节炎患者血小板参数变化及关联规则研究[J].中国临床保健杂志,2019,22(1):72-78.
基于数据挖掘的老年骨关节炎患者血小板参数变化及关联规则研究
The changes of platelet parameter and association rules in elderly patients with osteoarthritis
投稿时间:2018-01-15  
DOI:10.3969/J.issn.1672-6790.2019.01.020
中文关键词: 骨关节炎  血小板  数据挖掘  老年人
英文关键词: Osteoarthritis  Blood platelets  Data mining  Aged 〖FL
基金项目:安徽省科技攻关项目(1604a0802085);中医药行业科研专项(201307001);2016年中央引导地方科技发展专项(财教〔2016〕1188);现代中医内科应用基础与开发研究安徽省重点实验室(财教〔2016〕518);2015年技术创新服务体系专项(财教〔2015〕1551)
作者单位E-mail
文建庭 安徽中医药大学研究生部,合肥 230038 1548325662@qq.com 
刘健 安徽省中医院风湿科 liujianahzy@126.com 
忻凌 安徽省中医院风湿科  
万磊 安徽省中医院风湿科  
董文哲 安徽中医药大学研究生部,合肥 230038  
方妍妍 安徽中医药大学研究生部,合肥 230038  
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中文摘要:
      目的 了解老年骨关节炎(OA)血小板参数的变化情况,并分析其与免疫、炎性及代谢等指标的关系。方法 运用数据挖掘的方法,选取安徽省中医院风湿免疫科4 151例OA患者,根据不同年龄段分成中青年组(18~59岁)、老年组(≥60岁),运用SPSS 23.0统计软件对不同年龄段OA患者血小板参数及免疫、炎性、代谢等指标进行相关性分析及二元logistic回归分析,并运用SPSS Clementine 11.1 软件中Aprior 模块对所有指标进行关联分析。结果 (1)共纳入4151例OA患者,其中中青年组2 187例(52.69%),老年组1 964例(47.31%);老年组PLT计数升高有987例(50.25%),中青年组PLT计数升高有938例(42.89%);老年组的血小板计数(PLT)、红细胞沉降率(ESR)、超敏C反应蛋白(hs-CRP)、补体C3、三酰甘油(TG)均高于中青年组,差异有统计学意义(P<0.05或P<0.01)。(2)由相关性分析得出,中青年组,OA患者PLT计数、血小板压积(PCT)均与ESR、hs-CRP、免疫球蛋白G(IgG)、补体C3呈正相关,PLT计数还与免疫球蛋白A(IgA)、免疫球蛋白M(IgM)呈正相关,血小板分布宽度(PDW)、血小板平均体积(MPV)与ESR、hs-CRP、补体C3呈负相关,PDW还与IgG呈负相关;老年组,OA患者PLT计数、PCT均与ESR、hs-CRP、IgA、IgG、IgM、补体C4呈正相关,PLT计数还与TG、低密度脂蛋白胆固醇(LDL-C)呈正相关,PDW、MPV均与ESR、hs-CRP、IgA、IgM、补体C3、补体C4呈负相关。由二元logistic回归分析得出,中青年组中,OA患者的性别、ESR、hs-CRP、IgM、补体C3、补体C4、LDL-C是PLT计数的危险因素,ESR、hs-CRP、IgA、补体C3、补体C3是PCT的危险因素,ESR、hs-CRP是PDW、MPV的危险因素。老年组中,OA患者的ESR、hs-CRP、IgG、IgM、补体C3、补体C4、TG、LDL-C是PLT计数的危险因素,ESR、hs-CRP、IgM、补体C4是PCT的危险因素,ESR、hs-CRP是PDW、MPV的危险因素。(3)由χ2检验得出,老年OA患者在PLT计数、PCT、ESR、hs-CRP、补体C3、补体C4指标升高率大于中青年组,差异有统计学意义(P<0.05或P<0.01)。(4)关联规则得出,老年OA患者PLT计数与ESR、hs-CRP、IgG、补体C3、补体C4的关联度以及PCT与ESR、IgA的关联度高于中青年组。结论 老年OA患者活动期血小板参数的变化大于中青年患者,且与免疫、炎性、代谢指标间关联度高于中青年患者,说明其表达的失调可能在老年OA的发病中发挥重要作用。
英文摘要:
      Objective To investigate the changes of platelet parameters in elderly osteoarthritis (OA) and analyze the relation between platelet parameters and the indexes of immunity,inflammation and metabolism.Method 4 151 patients with OA were selected by using the method of data mining.According to different age groups,these patients were divided into two groups:the young and middle-aged group (18-59 years old) and the elderly group (60 years old).The correlation analysis and binary logistic regression analysis between platelet parameters and the indexes of immune,inflammation,and metabolism of the patients with OA in different age groups were conducted by using SPSS 23.0 statistical software.The association analysis for all indexes were conducted by using the Aprior module of SPSS Clementine 11.1 software.Results (1) Of 4 151 cases of patients with OA 2 187 cases (52.69%) were in the young and middle-aged group and 1964 cases (47.31%) in the elderly group.The PLT count of 987 cases (50.25%) in the elderly group was increased,938 cases (42.89%) in the young and middle-aged group.The platelet count (PLT),the ESR,hs-CRP,the levels of complement C3 and glycerol three lipid (TG) in the elderly group were all higher than those in the young and middle-aged group (P<0.05 or P<0.01).(2) According to the correlation analysis,in the young and middle-aged group,the PLT count and platelet pressure (PCT) were positively correlated with ESR,hs-CRP,immunoglobulin G (IgG) and complement C3,and the PLT count was also positively correlated with immunoglobulin A (IgA),immunoglobulin M.In addition,the platelet distribution width (PDW) and the average volume of platelets (MPV) were negatively correlated with ESR,hs-CRP,and complement C3,and PDW of the patients was also negatively correlated with IgG.In the elderly group,the PLT count and PCT were positively correlated with ESR,hs-CRP,IgA,IgG,IgM and complement C4,and the PLT count was also positively correlated with TG and LDL-C.PDW and MPV were negatively correlated with ESR,hs-CRP,IgA,IgM,complement C3 and complement C4.According to binary logistic regression analysis,in the young and middle-aged group,the sex,ESR,hs-CRP,IgM,complement C3,complement C4 and LDL-C were the risk factors of PLT count;ESR,hs-CRP,IgM,complement C3,complement C4,and LDL-C were the risk factors of PCT;and ESR and hs-CRP were the risk factors of PDW and MPV.In the elderly group,ESR,hs-CRP,IgG,IgM,complement C3,complement C4,TG,LDL-C were the risk factors of PLT counts;ESR,hs-CRP,IgM and complement C4were the risk factors of PCT;ESR and hs-CRP were the risk factors of PDW and MPV.(3) From the Chi-square test,it can be concluded that the rate of increase of the indexes including PLT count,PCT,ESR,hs-CRP,complement C3 and complement C4 for the patients with OA in the elderly group was larger than that in the middle and young people (P<0.05 or P<0.01).(4) It can be obtained from the association rules that in the elderly group,the correlation between PLT count of the patients with OA and the indexes including ESR,hs-CRP,IgG,complement C3,complement C4 and the correlation between PCT and the indexes including ESR and IgA were higher than those in the young and middle age groups.Conclusion The changes of platelet parameters at the active stage for the patients with OA in the elderly group are greater than those in young and middle-aged group,and the correlation between platelet parameters and the indexes of immunity,inflammation and metabolism for the patients in the elderly group is higher than that in the young and middle-aged group,which indicates that such imbalance may play an important role in the onset of OA in the elderly.
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