文章摘要
余秋实,王志权,马志强,刘宁,朱启明.尼可地尔辅助治疗对稳定型心绞痛患者心功能、斑块稳定性及血管内皮功能的影响[J].中国临床保健杂志,2019,22(1):64-67.
尼可地尔辅助治疗对稳定型心绞痛患者心功能、斑块稳定性及血管内皮功能的影响
Effect of nicorandil adjuvant treatment on heart function,stability of plaque and vascular endothelial function in patients with stable angina pectoris of coronary heart disease
投稿时间:2018-02-20  
DOI:10.3969/J.issn.1672-6790.2019.01.018
中文关键词: 心绞痛  内皮,血管  斑块,动脉粥样硬化
英文关键词: Angina Pectoris  Endothelium,vascular  Plaque,atherosclerotic 〖FL
基金项目:湖北省卫生计生西医类一般项目(WJ2015Z048)
作者单位E-mail
余秋实 中国人民解放军第一六一医院心内科,武汉 430010 aaa8575864@163.com 
王志权 中国人民解放军第一六一医院心内科,武汉 430010  
马志强 中国人民解放军第一六一医院心内科,武汉 430010  
刘宁 中国人民解放军第一六一医院心内科,武汉 430010  
朱启明 中国人民解放军第一六一医院心内科,武汉 430010 lxsnkl@163.com 
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中文摘要:
      目的 研究尼可地尔辅助治疗对稳定型心绞痛患者心功能、斑块稳定性及血管内皮功能的影响。方法 选取482例稳定型心绞痛患者,根据随机数字表法将患者分为2组,对照组和研究组各241例。对照组患者给予酒石酸美托洛尔片、阿司匹林肠溶片、阿托伐他汀钙片联合治疗,研究组在对照组的基础上给予尼可地尔辅助治疗。治疗3个月,比较两组患者的临床总有效率、不良反应发生率、心脏指数(CI)、左室射血分数(LVEF)、左室短轴缩短分数(LVFS)、血清中五聚素-3(PTX3)、脂蛋白相关的磷脂酶A2(Lp-PLA2)的水平以及血浆中内皮素-1(ET-1)、一氧化氮(NO)水平等。结果 研究组患者的总有效率为90.04%,显著高于对照组的78.01%(P<0.05);治疗后研究组CI、LVEF、LVFS水平分别为(2.97±0.54)L·min-1·m-2、(66.34±7.56)%、(35.67±4.82)%,均高于对照组的(2.75±0.48)L·min-1·m-2、(63.26±7.34)%、(33.78±4.53)%(P<0.05)。治疗后研究组血清中PTX3、Lp-PLA2水平分别为(2.17±0.24)μg/L、(18.63±4.64)μg/L,均低于对照组的(2.62±0.28)μg/L、(38.97±4.98)μg/L,均P<0.05。治疗后研究组血浆ET-1水平为(102.51±12.47)ng/L,显著低于对照组的(116.84±13.14)ng/L,P<0.05;NO水平为(78.51±5.26)μmol/L,显著高于对照组的(51.63±4.92)μmol/L,P<0.05。研究组的不良反应发生率为1.24%,与对照组的0.83%比较,差异无统计学意义(P>0.05)。结论 尼可地尔辅助治疗对稳定型心绞痛患者具有较好的临床疗效,可改善患者的心功能、血管内皮功能,并可提升斑块稳定性,安全性较好。
英文摘要:
      Objective To study the effect of nicorandil adjuvant treatment on heart function,stability of plaque and vascular endothelial function in patients with stable angina pectoris of coronary heart disease.Methods 482 patients with stable angina pectoris of coronary heart disease were selected,and all patients were randomly divided into control group and study group with 241 cases in each group according to the random number table method.The patients in the control group were collectively treated with Metoprolol Tartrate Tablets,Aspirin Enteric-coated Tablets and Atorvastatin Calcium Tablets.The patients in the study group were given nicorandil adjuvant treatment on the basis of the control group.Both of the patients in the two groups were treated for 3 months.Some indexes of the patients in the two groups were compared,including the clinical total effective rate,the incidence of adverse reactions,cardiac index (CI),left ventricular ejection fraction (LVEF),left ventricular fractional shortening (LVFS),the levels of serum pentraxin-3 (PTX3) and lipoprotein associated phospholipase A 2(Lp-PLA2),and the levels of plasma endothelin-1 (ET-1) and nitric oxide (NO).Results The total effective rate of the patients in the study group was 90.04%,which was significantly higher than that in the control group 78.01% (P<0.05).After treatment,the levels of CI,LVEF and LVFS of patients in the study group were (2.97±0.54) L·min-1·m-2,(66.34±7.56)%,(35.67±4.82)%,which were respectively higher than those in the control group (2.75±0.48) L·min-1·m-2,(63.26±7.34)% and(33.78±4.53)%,P<0.05;the levels of serum PTX3 and Lp-PLA2 in the study group were (2.17±0.24) μg/L,(18.63±4.64) μg/L,which were respectively lower than those in the control group (2.62±0.28) μg/L,and (38.97±4.98) μg/L (P<0.05);the level of ET-1 in the study group was (102.51±12.47) ng/L,which was lower than that in the control group (116.84±13.14) ng/L (P<0.05);the level of NO of patients in the study group was (78.51±5.26) μmol/L,which was higher than that in the control group (51.63±4.92) μmol/L(P<0.05).There was no statistical significance in the difference between the incidences of adverse reactions of patients in the study group and the control group,which were 1.24% and 0.83%.Conclusion Nicorandil adjuvant treatment has good clinical curative effect to the patients who have stable angina pectoris of coronary heart disease.It can improve heart function and vascular endothelial function of patients,and improve the stability of plaque with good safety.
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