文章摘要
王静蓉,王秀娟,何蕾,皇鑫,杨斌.无创正压通气联合法舒地尔治疗慢性肺源性心脏病合并Ⅱ型呼吸衰竭的临床疗效[J].中国临床保健杂志,2019,22(1):56-59.
无创正压通气联合法舒地尔治疗慢性肺源性心脏病合并Ⅱ型呼吸衰竭的临床疗效
Clinical effect of noninvasive positive pressure ventilation combined with fasudil in patients with CPHD complicated with type Ⅱ respiratory failure
投稿时间:2017-11-23  
DOI:10.3969/J.issn.1672-6790.2019.01.016
中文关键词: 肺心病  呼吸功能不全  正压呼吸  蛋白激酶抑制剂
英文关键词: Pulmonary heart disease  Respiratory insufficiency  Positive-pressure respiration  Protein kinase inhibitors 〖FL
基金项目:云南省科技厅-昆明医科大学应用基础联合专项(2014FB089)
作者单位E-mail
王静蓉 云南省第一人民医院重症医学科,昆明 650032 529334553@qq.com 
王秀娟 天津市人民医院  
何蕾 云南省第二人民医院感控办 drh541@163.com 
皇鑫 云南省第一人民医院重症医学科,昆明 650032  
杨斌 云南大理州医院普外二科  
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中文摘要:
      目的 分析慢性肺源性心脏病(CPHD)合并Ⅱ型呼吸衰竭应用不同方法治疗的临床疗效,并探讨最佳治疗方案。方法 将132例慢性肺源性心脏病合并Ⅱ型呼吸衰竭患者作为研究对象,采用分层、随机方法,将132例患者分为两组,即研究组与对照组,每组均是66例。两组患者均予以常规模式的治疗,在此基础上,对照组患者联合应用无创正压通气治疗,研究组患者联合应用无创正压通气加法舒地尔治疗。观察两组治疗前后呼吸及心率指标、动脉血气分析指标、预后指标和炎性因子指标变化。结果 两组患者治疗后呼吸及心率指标、动脉血气分析指标、炎性因子指标较治疗前有显著的改善,且研究组改善效果要优于对照组患者,组间差异有统计学意义(均P<0.05)。研究组无创通气时间[(112.4±7.9)h比(138.6±8.4)h,t=18.458,P=0.001]、住院时间[(11.2±3.4)d比(14.3±4.7)d,t=4.341,P=0.001],均明显优于对照组(P<0.05)。研究组临床治疗总有效数[62例(93.94%)比53例(80.30%),χ2=5.469,P=0.019],与对照组相比也有明显差异(P<0.05)。结论 无创正压通气联合法舒地尔治疗CPHD合并Ⅱ型呼吸衰竭的疗效确切,症状改善明显。
英文摘要:
      Objective To analyze the clinical efficacy of using different methods to treat the patients with chronic pulmonary heart disease (CPHD) complicated with type Ⅱ respiratory failure.Methods A total of 132 patients with CPHD complicated with type Ⅱ respiratory failure were selected as object of study.By using the stratified and randomized method,these patients were divided into two groups,which were an experimental group and a control group.There were 66 patients in each group.On the basis of providing the patients in the two groups with conventional mode of treatment,the patients in the control group were given the treatment of noninvasive positive pressure ventilation and the patients in the experimental group were given the treatment of noninvasive positive pressure ventilation combined with fasudil.The changes of the indicator of respiratory and heart rate,the analysis indicator of arterial blood gas,the prognostic indicator and the indicator of inflammatory factor of the patients in the two groups were observed before and after treatment.Results The indicator of arterial blood gas,and the indicator of inflammatory factors of two groups were significantly improved after treatment.The effect of improvement in the experimental group was better than that in the control group and the difference between them was statistically significant (P<0.05). Conclusion The treatment of noninvasive positive pressure ventilation combined with fasudil is effective for the patients with CPHD complicated with type Ⅱ respiratory failure,and the symptoms are significantly improved.
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