文章摘要
周巧,刘健,忻凌,宋倩,郭锦晨,黄旦.老年性湿热型骨关节炎患者超氧化物歧化酶活性的变化及关联规则研究[J].中国临床保健杂志,2019,22(1):39-42.
老年性湿热型骨关节炎患者超氧化物歧化酶活性的变化及关联规则研究
Study on the change and association rule of superoxide dismutase in senile osteoarthritis patients with damp-heat syndrome
投稿时间:2018-07-10  
DOI:10.3969/J.issn.1672-6790.2019.01.012
中文关键词: 骨关节炎  超氧化物歧化酶  危险因素  老年人
英文关键词: Osteoarthritis  Superoxide dismutase  Risk factors  Aged 〖FL
基金项目:中央引导地方科技发展专项[财教〔2016〕1188];安徽省科技攻关项目(1604a0802085);现代中医内科应用基础与开发研究安徽省重点实验室[财教〔2016〕518]
作者单位E-mail
周巧 安徽中医药大学第二附属医院,合肥 230061 liujianahzy@126.com 
刘健 安徽中医药大学第一附属医院 liujianahzy@126.com 
忻凌 安徽中医药大学第一附属医院 liujianahzy@126.com 
宋倩 安徽中医药大学 liujianahzy@126.com 
郭锦晨 安徽中医药大学 liujianahzy@126.com 
黄旦 安徽中医药大学 liujianahzy@126.com 
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中文摘要:
      目的 研究老年性湿热型骨关节炎患者血清中超氧化物歧化酶(SOD)活性的变化及与免疫炎症等指标的关系。方法 整理安徽省中医院风湿免疫科2012年6月至2017年6月骨关节炎(OA)住院患者的病历资料,观察血清SOD活性变化,并与年龄、病程及免疫、炎症,代谢等实验室指标进行相关性分析及logistic回归分析。结果 (1)1904例湿热证骨关节炎患者,中青年组1115例,老年组789例,老年组SOD下降者有484例,占61.3%;中青年组SOD下降者有312例,占27.9%。(2)老年组SOD与红细胞沉降率(ESR)、超敏C反应蛋白(hs-CRP)、三酰甘油(TG)、载脂蛋白-B(Apo-B)、补体C4呈负相关,与免疫球蛋白G(IgG)呈正相关(P<0.05)。(3)ESR、hs-CRP、IgG、高密度脂蛋白胆固醇(HDL-C)是老年组SOD的危险因素。(4)老年组SOD与ESR、hs-CRP、IgG、免疫球蛋白M(IgM)的关联度高于中青年组。结论 老年OA患者血清SOD下降可能参与了OA的发病。
英文摘要:
      Objective To study the changes of serum superoxide dismutase activity in elderly patients with damp-heat syndrome of osteoarthritis and the relationship with immune inflammation and other indicators.Methods The clinical data of hospitalized patients with osteoarthritis were collected.Syndrome differentiation of traditional Chinese medicine belongs to syndrome dampness-heat blocking collateral.We have analyzed the changes of superoxide dismutase,and correlation with age,disease duration and immunological inflammation and other laboratory indicators.The relationship between SOD and immune inflammation was analyzed by SPSS Clementine 12.0 software Aprior module.Results (1) In 1904 patients with damp-heat syndrome,there were 1155 cases of middle-aged and young patients group and 789 cases of elderly patients group.There were 484 cases (61.3%) in the elderly patients group and 312 cases (27.9%) in the middle-aged and young patients group.(2) The chi-square test showed that the descending rate of SOD in the elderly group was higher than that in the middle-aged group (P<0.01).The rising rates of ESR,hs-CRP,IgG and IgM in the elderly group were higher than those in the middle (P<0.05 or P<0.01).(3) Correlation analysis showed that there was a negative correlation between SOD and ESR,hs-CRP,TG,Apo-B,Complement C4,and IgG was positively correlated (P<0.05).(4) Logistic regression analysis showed that ESR,hs-CRP,IGG and HDL-C were the risk factors of SOD in elderly group.(5) The association rules showed that the correlation between SOD and ESR,hs-CRP,IgG and IgM in elderly group was higher than that in middle-aged and young group.Conclusion Decreased expression of serum SOD in elderly patients with OA may be involved in the pathogenesis.
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