文章摘要
马峰,朱文丽.稳定期慢性阻塞性肺疾病患者血清血管黏附蛋白-1、分泌型卷曲相关蛋白1水平与气流受限和生活质量的相关性[J].中国临床保健杂志,2019,22(1):32-35.
稳定期慢性阻塞性肺疾病患者血清血管黏附蛋白-1、分泌型卷曲相关蛋白1水平与气流受限和生活质量的相关性
Correlation analysis of serum VAP-1 and SFRP-1 levels with airflow limitation and quality of life in patients with stable chronic obstructive pulmonary disease
投稿时间:2018-07-20  
DOI:10.3969/J.issn.1672-6790.2019.01.010
中文关键词: 肺疾病,慢性阻塞性  肺通气  生活质量  健康状况指标
英文关键词: Pulmonary disease,chronic obstructive  Pulmonary ventilation  Quality of life  Health status indicators 〖FL
基金项目:
作者单位E-mail
马峰 北京大学公共卫生学院,北京 100191 mf1039@163.com 
朱文丽 航天中心医院呼吸科 zhuwenli@bjmu.edu.cn 
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中文摘要:
      目的 探讨稳定期慢性阻塞性肺疾病(COPD)患者血清血管黏附蛋白-1(VAP-1)、分泌型卷曲相关蛋白1(SFRP-1)水平与气流受限和生活质量的相关性,为临床诊治提供理论依据。方法 选取稳定期COPD患者167例作为研究组,根据COPD全球倡议(GOLD)对患者进行分级;选取84名同期健康体检人群作为对照组。采用ELISA法检测血清VAP-1、SFRP-1水平,患者整个肺活量占预计值百分比(FVC% pred)、第1秒用力呼气容积占预计值的百分比(FEV1% pred)、第1秒用力呼气容积/用力肺活量百分比(FEV1/FVC)等肺功能指标,采用COPD评估测试量表(CAT)评定COPD患者的生活质量,分析血清VAP-1、SFRP-1水平与气流受限指标和生活质量的相关性。结果 观察组患者血清VAP-1、SFRP-1水平高于对照组(P<0.05),血清VAP-1、SFRP-1水平随着COPD患者病情严重程度和CAT评分增加(P<0.05);FVC% pred、FEV1% pred、FEV1/FVC水平随着COPD患者病情严重程度和CAT评分下降(P<0.05)。血清VAP-1、SFRP-1水平与FVC% pred(r=-0.759,r=-0.503,P均<0.05)、FEV1% pred(r=-0.626,r=-0.683,P均<0.05)及FEV1/FVC(r=-0.581,r=-0.637,P均<0.05)呈负相关,与 CAT评分(r=0.712,r=0.574,P均<0.05)、GOLD分级呈正相关(r=0.755,r=0.642,P均<0.05)。结论 血清VAP-1、SFRP-1水平与稳定期COPD患者病情严重程度、气流受限和生活质量密切相关,可作为反映稳定期COPD患者病情的生物学指标。
英文摘要:
      Objective To investigate the correlation of serum vascular adhesion protein-1 (VAP-1) and secretory curl related protein 1 (SFRP-1) with air flow limitation and quality of life in patients with stable COPD (chronic obstructive pulmonary disease) and provide a theoretical basis for clinical diagnosis and treatment.Methods 167 patients with stable period of COPD were selected as the research group,which were classified according to the COPD Global Initiative (GOLD).84 healthy people were selected as the control group.The serum VAP-1 and SFRP-1 levels were detected by Elisa,and FVC% pred,FEV1% pred,FEV1/FVC and other lung function indexes were measured.The quality of life was analyzed by assessment test scale (CAT).To analyze the correlation of VAP-1,SFRP-1 levels with air flow limitation and quality of life in patients with stable COPD.Results The level of serum VAP-1 and SFRP-1 in the observation group were higher than those in the control group (P<0.05),and the level of serum VAP-1 and SFRP-1 increased with the severity of COPD patients (P<0.05),FVC% pred,FEV1% pred and FEV1/FVC levels were higher than those in the control group (P<0.05).The FVC% pred,FEV1% pred,FEV1/FVC and CAT levels decreased with severity of the disease (P<0.05).The level of serum VAP-1 and SFRP-1 has a negative correlation with FVC% pred (r=-0.759,r=-0.503,P<0.05),FEV1% pred (r=-0.626,r=-0.683,P<0.05) and FEV1/FVC (r=-0.581,r=-0.637,P<0.05),which were also positively correlated with CAT score (r=0.712,r=0.574,P<0.05) and GOLD classification (r=0.755,r=0.642,P<0.05).Conclusion The levels of serum VAP-1 and SFRP-1 in patients with stable COPD are closely related to the severity of airflow obstruction,the quality of life and the degree of hypoxia,and thus they may be used as indicators of the control and quality of life of patients with stable COPD.
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