文章摘要
李敏,袁丽洁,杜文婷,唐怀滨.队列人群代谢综合征与心脑血管事件关系的回顾性研究[J].中国临床保健杂志,2018,21(6):804-807.
队列人群代谢综合征与心脑血管事件关系的回顾性研究
A retrospective study on the association between metabolic syndrome and cardiovascular and cerebrovascular events in cohort population
投稿时间:2018-06-20  
DOI:10.3969/J.issn.1672-6790.2018.06.021
中文关键词: 疾病管理  心血管疾病  脑血管障碍  代谢综合征  回顾性研究
英文关键词: Disease management  Cardiovascular diseases  Cerebrovascular disorders  Metabolic syndrome  Retrospective studies 〖FL
基金项目:陕西省科学技术研究发展计划项目(2016SF-310)
作者单位E-mail
李敏 陕西省人民医院干部保健办,西安 710068 794796840@qq.com 
袁丽洁 陕西省人民医院医务处感染科,西安 710068 794796840@qq.com 
杜文婷 陕西省人民医院干部保健办,西安 710068 794796840@qq.com 
唐怀滨 陕西省人民医院干部体检中心,西安 710068 794796840@qq.com 
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中文摘要:
      目的 探讨代谢综合征(MS)及其各组分与心脑血管疾病之间的关系,为慢性病管理提供依据和策略。方法 以2006年6月至2007年12月间参加健康体检的男性厅级干部为研究对象,分为MS组和非MS组,于2016年底通过医保系统查阅研究对象10年住院信息资料,进行集中随访,研究心脑血管终点事件发生情况。结果 共纳入研究对象1334人,其中MS组467人,非MS组867人,MS患病率35%。基线状态下两组各代谢指标除总胆固醇、低密度脂蛋白外,差异均有统计学意义。观察期内,共有179人发生终点事件,MS组和非MS组冠心病事件、缺血性脑卒中的10年累积发病率差异有统计学意义(P<0.05),两种疾病的发病风险MS组分别为非MS组的1.95倍和1.75倍。随着MS组分增多,心脑血管发病相对危险度增大。结论 MS者发生冠心病事件、缺血性脑卒中的风险明显增加,但与出血性脑卒中的关系需要进一步探讨。MS组分与终点事件之间存在剂量反应关系。
英文摘要:
      Objective To explore the association between metabolic syndrome (MS) and cardiovascular and cerebrovascular diseases,and provide basis and strategy for the management of chronic diseases.Method To study the occurrence of cardiovascular and cerebrovascular endpoint events.A baseline survey was conducted on male cadres of director level who took part in the physical examination between June,2006 and December,2007.The subjects were divided into MS group and non-MS group.A follow-up study was carried on to obtain 10 years of hospitalization information of the study subjects through the provincial medical insurance system in the end of 2016.Result A total of 1334 individuals were enrolled in the study,467 in MS group and 867 in non-MS group.The incidence of MS at baseline was 35%.There were significant differences in metabolic indexes except total cholesterol and low density lipoprotein between the two groups.During the observation period,a total of 179 patients had terminal events.There was significant difference in the cumulative incidence of coronary heart disease and ischemic stroke between MS group and non-MS group (P<0.05).The risk of disease in MS group was 1.95 times and 1.75 times higher than that in non-MS group respectively.Conclusion Metabolic syndrome is associated with an increased risk of coronary heart disease and ischemic stroke,but the relationship with hemorrhagic stroke needed to be further explored.There was a dose-response relationship between the components of MS and the endpoint events.
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