文章摘要
李杰,赵卫东,王慧妍,李宝珠,吴潇,任萍萍,赵旭旭.错配修复基因缺陷对卵巢癌预后影响的系统评价[J].中国临床保健杂志,2018,21(6):771-776.
错配修复基因缺陷对卵巢癌预后影响的系统评价
A systematic review of the effects of mismatch repair gene defects on the prognosis of ovarian cancer
投稿时间:2018-02-08  
DOI:10.3969/J.issn.1672-6790.2018.06.013
中文关键词: 卵巢肿瘤  DNA错配修复  微卫星不稳定性  预后  评价研究
英文关键词: Ovarian neoplasms  DNA mismatch repair  Microsatellite instability  Prognosis  Evaluation studies 〖FL
基金项目:安徽省科技厅资助项目(1604f0804010)
作者单位E-mail
李杰 安徽医科大学附属省立医院、安徽省立医院妇产科,合肥 230001 victorzhao@163.com 
赵卫东 安徽医科大学附属省立医院、安徽省立医院妇产科,合肥 230001
安徽省肿瘤医院妇瘤科 
victorzhao@163.com 
王慧妍 安徽省肿瘤医院妇瘤科 victorzhao@163.com 
李宝珠 安徽医科大学流行病与卫生统计学系 victorzhao@163.com 
吴潇 安徽医科大学附属省立医院、安徽省立医院妇产科,合肥 230001 victorzhao@163.com 
任萍萍 安徽医科大学附属省立医院、安徽省立医院妇产科,合肥 230001 victorzhao@163.com 
赵旭旭 安徽医科大学附属省立医院、安徽省立医院妇产科,合肥 230001 victorzhao@163.com 
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中文摘要:
      目的 系统评价错配修复(MMR)基因缺陷与卵巢癌预后的关系。方法 检索从建库至2017年6月15日PubMed、EMBASE、Cochrane、中国学术期刊全文数据库、维普和万方数据库收录的关于错配修复(MMR)基因缺陷与卵巢癌患者预后相关性关系的文献,筛选出符合纳入标准的文献进行循证评价,主要评价指标包括总生存期(OS)和无病生存期(DFS),应用风险比(hazard ratio,HR)和95%CI来评价结局指标,采用RevMan5.3软件进行Meta分析。结果 共纳入8篇文献,3966例患者,研究间异质性较大。其中一篇文献显示MMR基因缺陷与卵巢癌预后有显著相关性(HR=0.41,P=0.007),合并分析显示MMR与卵巢癌患者OS间无统计学意义(3篇研究,HR=0.84,95%CI 0.60~1.19,P=0.33)。结论 MMR基因缺陷与卵巢癌预后之间尚未发现显著相关性,可能是由于缺乏足够的相关研究,有待于未来更多高质量的大样本试验进一步研究。
英文摘要:
      Objective To evaluate systematically the relationship between the deficiency in mismatch repair (MMR) genes and prognosis among women with ovarian cancer. Methods Studies of the relationship between mismatch repair (MMR) gene defects and prognosis of ovarian cancer patients were retrieved from PubMed,EMBASE,Cochrane,CNKI,VIP and Wanfang Database from their building time to June 15,7.Literature that meets inclusion criteria were filtrated for evidence-based evaluation,where the main evaluation indexes included overall survival (OS) and disease-free survival (DFS),while hazard ratio (HR) and 95%CI were used to evaluate the outcome index and Meta-analysis was performed using RevMan 5.3 software. Results 3966 patients were included in 8 literatures,and heterogeneity between the studies was significant.One of the literatures showed a significant correlation between MMR gene defects and ovarian cancer prognosis(HR=0.41,P=0.007),and the combined analysis showed no statistically significance between MMR and OS in patients with ovarian cancer (3 studies,HR:0.84,5% CI:0.60-1.19,P=0.33). Conclusion There is no definitive evidence of a significant association between mismatch repair (MMR) gene defects and prognosis of ovarian cancer,which may due to the lack of sufficient relevant researches,and needs to be further studied in the future with higher quality and lager-scale sample trial.
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