文章摘要
杨俊,曾俊,王稳,代敏,陈芳媛,杨建明.环氧化酶-2水平和脂代谢指标在糖尿病心肌病患者体内的变化特点及意义[J].中国临床保健杂志,2018,21(6):764-767.
环氧化酶-2水平和脂代谢指标在糖尿病心肌病患者体内的变化特点及意义
Changes of COX-2 and lipid metabolism in patients with diabetic cardiomyopathy
投稿时间:2018-06-27  
DOI:10.3969/J.issn.1672-6790.2018.06.011
中文关键词: 糖尿病心肌病  环氧化酶2  血脂异常  利钠肽,C型
英文关键词: Diabetic cardiomyopathies  Cyclooxygenase 2  Dyslipidemias  Natriuretic peptide,C-type 〖FL
基金项目:中国博士后科学基金第61批资助项目(2017M612702)
作者单位E-mail
杨俊 三峡大学人民医院 宜昌市第一人民医院内分泌科,宜昌 443000 81488839@qq.com 
曾俊 三峡大学人民医院 宜昌市第一人民医院内分泌科,宜昌 443000 junzeng@live.com 
王稳 三峡大学人民医院 宜昌市第一人民医院内分泌科,宜昌 443000  
代敏 三峡大学人民医院 宜昌市第一人民医院内分泌科,宜昌 443000  
陈芳媛 三峡大学人民医院 宜昌市第一人民医院内分泌科,宜昌 443000  
杨建明 三峡大学人民医院 宜昌市第一人民医院内分泌科,宜昌 443000  
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中文摘要:
      目的 研究环氧化酶-2(COX-2)水平和脂代谢指标在糖尿病心肌病患者体内变化特点及意义。方法 选取46例糖尿病心肌病患者设为观察组,选取同期单纯糖尿病患者40例设为对照组。记录并比较两组患者血脂指标、B型脑钠肽(BNP)、COX-2、血管紧张素转移酶2(ACE2)、基质金属蛋白酶组织抑制剂-2(TIMP-2)、基质金属蛋白酶-1(MMP-1)水平及心功能指标。结果 观察组患者病程长于对照组,总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、BNP、COX-2、ACE2、TIMP-2、肌酸激酶同工酶(CK-MB)水平高于对照组,高密度脂蛋白胆固醇(HDL-C)、MMP-1、左室射血分数(LVEF)、E峰/A峰比值水平低于对照组,差异有统计学意义(P<0.05)。结论 糖尿病心肌病患者体内BNP、COX-2、ACE2、TIMP-2水平显著上升,心功能指标下降,且脂代谢指标改变较为明显,为临床诊断糖尿病心肌病提供参考。
英文摘要:
      Objective To investigate the changes and significance of cyclooxygenase-2(COX-2) level and lipid metabolism in patients with diabetic cardiomyopathy(DM). Methods Forty-six patients with diabetic cardiomyopathy were selected as observation group and 40 patients with diabetes were selected as control group.The serum lipid,type B brain natriuretic peptide (BNP),angiotensin transferase (ACE2),tissue inhibitor of matrix metalloproteinase(MMP-2),matrix metalloproteinase-1(MMP-1) and cardiac function were recorded and compared between the two groups. Results The course of the observation group was longer than that in the control group.The total cholesterol TCU,triglyceride TGN,low density lipoprotein cholesterol BNP,COX-2,ACE2,TIMP-2 and creatine kinase isoenzyme CK-MB of the observation group were higher than those in the control group.The high density lipoprotein cholesterol (HDL-C),left ventricular ejection fraction (LVEF) and ratio of peak E/A were significantly lower than those in the control group(P<0.05),the difference was statistically significant. Conclusion The levels of serum BNP,COX-2,ACE2,TIMP-2 are increased significantly in patients with diabetic cardiomyopathy,and the cardiac function is decreased,and lipid metabolism changed significantly.
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