文章摘要
何挺,谢琛红.氟西汀治疗老年癫痫伴轻中度抑郁患者的效果[J].中国临床保健杂志,2018,21(6):745-748.
氟西汀治疗老年癫痫伴轻中度抑郁患者的效果
Effect of Fluoxetine in elderly epilepsy patients with moderate depression
投稿时间:2018-08-20  
DOI:10.3969/J.issn.1672-6790.2018.06.006
中文关键词: 癫痫  氟西汀  抑郁  老年人
英文关键词: Epilepsy  Fluoxetine  Depression  Aged 〖FL
基金项目:浙江省医药卫生科技计划立项项目(2013KYB268)
作者单位E-mail
何挺 浙江绍兴市第七人民医院神经内科,312000 htytt1234@sina.com 
谢琛红 浙江绍兴市第七人民医院老年科,312000  
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中文摘要:
      目的 探讨氟西汀治疗老年癫痫伴轻中度抑郁患者的临床效果。方法 选取92例老年癫痫伴轻中度抑郁患者作为研究对象。按照随机数字表法将其分为对照组与研究组,每组各46例,两组均根据患者实际病情给予常规抗癫痫治疗,其中对照组给予常规心理疏导,而研究组则加用氟西汀进行治疗,对比两组治疗后临床学效果。结果 研究组治疗效果明显优于对照组;治疗前及治疗2周后两组患者的HAMD评分差异无统计学意义(P>0.05);治疗4周、6周、8周后,研究组HAMD评分明显低于对照组,差异有统计学意义(P<0.05);两组治疗后不良反应差异均无统计学意义(P>0.05)。结论 氟西汀治疗老年癫痫伴轻中度抑郁疗效肯定,有效缓解患者的临床症状,改善其情绪状态,且药物间相互作用少,用药安全性高。
英文摘要:
      Objective To appraise the clinical effect of Fluoxetine in elderly epilepsy patients with moderate depression.Methods A total of 92 elderly epilepsy patients with moderate depression were selected.The subjects were randomly assigned to test group and control group,46 cases each group.According to the patients′ illness conditions,both groups took the conventional anti-epileptic agents.The test group also took the Fluoxetine in the same time.The clinical effects were compared.Results The treatment effect of test group was significantly better than that of control group;before treatment and after 2 weeks of treatment,the HAMD (Hamilton Depression Scale) points of two groups were not significantly different (P>0.05);after 4 weeks,6 weeks and 8 weeks of treatment,the HAMD points of test group were significantly lower than that of control group (P<0.05),the adverse event rate for two groups was not significantly different (P>0.05).Conclusion The Fluoxetine can effectively relieve the clinical symptoms,improve the emotional state,reduce the adverse reactions and increase the clinical safety.
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