文章摘要
顾磊,肖婕,文斐.骨桥蛋白、淋巴细胞活化基因-3、Dickkopf相关蛋白1在胃癌组织中的表达及与临床病理特征的相关性[J].中国临床保健杂志,2018,21(5):648-651.
骨桥蛋白、淋巴细胞活化基因-3、Dickkopf相关蛋白1在胃癌组织中的表达及与临床病理特征的相关性
Correlation research on the clinical expressions of OPN,sLAG-3 and DKK-1 in the gastric cancer tissues with its clinical pathological features
投稿时间:2018-06-18  
DOI:10.3969/J.issn.1672-6790.2018.05.021
中文关键词: 胃肿瘤  基因表达调控  骨桥蛋白质  病理状态,体征和症状
英文关键词: Stomach neoplasms  Gene expression regulation  Osteopontin  Pathological conditions,signs and symptoms 〖FL
基金项目:湖北省黄石市医疗卫生科技计划项目(HSYL2015000081)
作者单位E-mail
顾磊 鄂东医疗集团黄石市中心医院湖北理工学院附属医院病理科,黄石 435000 gulei610@163.com 
肖婕 鄂东医疗集团黄石市中心医院湖北理工学院附属医院病理科,黄石 435000  
文斐 鄂东医疗集团黄石市中心医院湖北理工学院附属医院病理科,黄石 435000  
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中文摘要:
      目的 探讨骨桥蛋白(OPN)、淋巴细胞活化基因-3(sLAG-3)、Dickkopf相关蛋白1(DKK-1)在胃癌组织中的表达及临床病理特征。方法 选取160例胃癌患者,分析OPN、sLAG-3、DKK-1表达同患者临床病理特征之间的关系,并对比三者在胃癌组织、癌旁组织以及正常胃黏膜组织当中的阳性表达情况。结果 OPN蛋白在胃癌组织当中的表达同分化程度、淋巴结转移、浸润深度以及胃癌分期等存在显著相关性(P<0.05);sLAG-3在胃癌组织当中的表达同患者的胃癌分期、浸润深度以及分化程度等存在显著相关性(P<0.05);DKK-1蛋白在胃癌组织当中的表达同分化程度、淋巴结转移、浸润深度以及胃癌分期等存在显著相关性(P<0.05);胃癌组织当中OPN、sLAG-3以及DKK-1表达阳性率显著高于癌旁组织以及正常胃黏膜组织(P<0.05)。结论OPN、sLAG-3、DKK-1表达与胃癌分期、浸润深度以及淋巴结转移等因素存在密切联系,能够评估患者的病情及预后质量。
英文摘要:
      Objective To analyze the correlation of the expressions of OPN,sLAG-3 and DKK-1 in the gastric cancer tissues with its clinical pathological features.Method 160 gastric cancer patients were selected.The correlation of the clinical expressions of OPN,sLAG-3 and DKK-1 with its clinical pathological features were analyzed;the positive rate of OPN,sLAG-3 and DKK-1 in the gastric cancer tissues,para-carcinoma tissues and normal gastric mucosa tissues was compared.Result In the gastric cancer tissues,the clinical expressions of OPN had an obvious correlation with the differentiated degree,lymphatic metastasis,infiltration depth and clinical staging of gastric cancer(P<0.05);in the gastric cancer tissues,the clinical expressions of sLAG-3 had an obvious correlation with the clinical staging of gastric cancer,infiltration depth and differentiated degree(P<0.05);in the gastric cancer tissues,the clinical expressions of DKK-1 had an obvious correlation with the differentiated degree,lymphatic metastasis,infiltration depth and clinical staging of gastric cancer(P<0.05);the positive rate of OPN,sLAG-3 and DKK-1 in the gastric cancer tissues was significantly higher than that of para-carcinoma tissues and normal gastric mucosa tissues(P<0.05).Conclusion In the gastric cancer tissues,the expressions of OPN,sLAG-3 and DKK-1 have a close correlation with the clinical staging of gastric cancer,infiltration depth and lymphatic metastasis,which it is helpful to evaluate the patient′s illness conditions and clinical prognosis.
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