文章摘要
胡倩,郑丽芳,王希佳,周子英,管倩倩.神经生长因子与奥拉西坦联合治疗对高血压脑出血患者的应用效果[J].中国临床保健杂志,2018,21(5):644-647.
神经生长因子与奥拉西坦联合治疗对高血压脑出血患者的应用效果
Analysis of the effect of combined treatment of nerve growth factor and oxiracetam on patients with hypertensive intracerebral hemorrhage
投稿时间:2018-06-16  
DOI:10.3969/J.issn.1672-6790.2018.05.020
中文关键词: 颅内出血,高血压性  神经生长因子  中枢神经系统药物  神经康复
英文关键词: Intracranial hemorrhage,Hypertensive  Nerve growth factor  Central nervous system agents  Neurological rehabilitation 〖FL
基金项目:湖北省武汉市卫生计生委医疗卫生科研项目(WX15D04)
作者单位E-mail
胡倩 湖北武汉市普仁医院神经内科,武汉 430080 575163506@qq.com 
郑丽芳 湖北武汉市普仁医院神经内科,武汉 430080 575163506@qq.com 
王希佳 湖北武汉市普仁医院神经内科,武汉 430080 575163506@qq.com 
周子英 湖北武汉市普仁医院神经内科,武汉 430080 575163506@qq.com 
管倩倩 湖北武汉市普仁医院神经内科,武汉 430080 575163506@qq.com 
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中文摘要:
      目的 观察高血压脑出血患者应用神经生长因子与奥拉西坦联合治疗的临床疗效。方法 选取82例高血压性脑出血患者,按照随机数字表法,将患者分为观察组(n=42)和对照组(n=40)。对照组给予奥拉西坦治疗,观察组在此基础上,联合神经生长因子治疗。观察两组患者治疗前后血清C反应蛋白(CRP)、神经元特异性烯醇化酶(NSE)、神经功能缺损情况(NIHSS量表)及运动功能及日常生活能力[巴氏指数(BI)]。患者均随访半年,比较两组患者神经功能恢复情况[改良Rankin量表(mRS]]以及患者的并发症情况。结果 观察组治疗前与对照组治疗前患者CRP、NSE、NIHSS、BI、mRS比较,均差异无统计学意义(P>0.05);治疗后,两组患者CRP、NSE及NIHSS评分均有改善作用,但观察组各个评分均优对照组(P<0.05);治疗后,两组患者BI、mRS评分均较治疗前有所改善,但两组间评分差异无统计学意义(P<0.05);观察组并发症发生率与对照组差异无统计学意义(P>0.05)。结论 高血压脑出血患者应用神经生长因子与奥拉西坦联合治疗能够显著改善神经功能损伤、血清CRP水平、NSE水平,但对于患者的日常生活能力和神经功能的恢复效果有限。
英文摘要:
      Objective To observe the clinical efficacy of combined treatment of nerve growth factor and oxiracetam in hypertensive intracerebral hemorrhage patients.Methods A total of 82 patients with hypertensive cerebral hemorrhage were selected.Patients were divided into observation group(n=42) and control group(n=40) according to the random number table method.The control group was treated with oxiracetam,and the observation group was treated with nerve growth factor on a sub-base.C-reactive protein (CRP),neuron-specific enolase (NSE),neurological deficit (NIHSS scale),and motor function and daily living ability (Pap′s index,BI) were observed before and after treatment.All patients were followed up for half a year,and the neurological recovery (modified Rankin scale,mRS) and complications of the patients were compared between the two groups.Results There were no significant differences in serum CRP,NSE,NIHSS,BI and mRS between the observation group and the control group before treatment(P>0.05).After treatment,the CRP,NSE and NIHSS scores of the two groups were improved,but observed.The scores of the patients in the group were superior to the control group(P<0.05).After treatment,the scores of BI and mRS in the two groups were improved compared with those before treatment,but there was no significant difference between the two groups(P<0.05).There was no significant difference between the incidence rate and the control group(P>0.05).Conclusion Combined treatment with nerve growth factor and oxiracetam in patients with hypertensive intracerebral hemorrhage can improve significantly neurological function damage,improve serum CRP,NSE levels,but the recovery effect of daily living ability and neurological function in patients with hypertensive intracerebral hemorrhage is limited.
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