文章摘要
张灿,陈康玉,王齐,鲍佩,丁晓梅,严激.血清胆红素变化对心脏再同步化治疗术后反应性预测的价值[J].中国临床保健杂志,2018,21(5):629-632.
血清胆红素变化对心脏再同步化治疗术后反应性预测的价值
The value of serum bilirubin in predicting postoperative reactivity after cardiac resynchronization therapy
投稿时间:2018-03-08  
DOI:10.3969/J.issn.1672-6790.2018.05.016
中文关键词: 心脏外科手术  心力衰竭  胆红素  手术后并发症
英文关键词: Cardiac surgical procedures  Heart failure  Bilirubin  Postoperative complications 〖FL
基金项目:中央引导地方科技发展专项(2016080802D113);安徽省卫生和计划生育委员会科研计划项目(2016QK002)
作者单位E-mail
张灿 中国科学技术大学附属第一医院安徽省立医院心内科,合肥 230001 289730793@qq.com 
陈康玉 中国科学技术大学附属第一医院安徽省立医院心内科,合肥 230001  
王齐 中国科学技术大学附属第一医院安徽省立医院心内科,合肥 230001  
鲍佩 中国科学技术大学附属第一医院安徽省立医院心内科,合肥 230001  
丁晓梅 中国科学技术大学附属第一医院安徽省立医院心内科,合肥 230001  
严激 中国科学技术大学附属第一医院安徽省立医院心内科,合肥 230001 yanji111111@126.com 
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中文摘要:
      目的 通过观察慢性心力衰竭患者心脏再同步化治疗(CRT)术前后血清胆红素水平变化,探讨血清胆红素变化与CRT治疗反应性的关系。方法 选取因慢性心力衰竭行CRT-P/D植入的患者,分别在术前及术后检测患者血清胆红素水平,分析胆红素水平变化与CRT疗效的关系。结果 共入选124例患者,其中随访CRT有反应组83例,CRT无反应组41例。CRT有反应组患者血清总胆红素水平降低(ΔTBIL)及间接胆红素的降低(ΔIBIL)较无反应组差异有统计学意义(P=0.008,P=0.016)。logistic回归分析提示,除性别、缺血性心肌病、完全性左束支传导阻滞之外,ΔTBIL是CRT有反应的独立预测因子(OR=1.073,95%CI:1.006~1.144,P=0.033)。结论 慢性心力衰竭患者CRT术后血清总胆红素水平降低是CRT有反应的独立预测因子。
英文摘要:
      Objective To analyze the relationship between serum bilirubin and the efficacy of CRT by observing the variation of serum bilirubin before and after CRT. Methods Patients underwent CRT were enrolled in this study.Serum bilirubin was deteced before and after CRT,and its relationship with the efficacy of CRT was evaluated. ResultsA total of 124 patients were included in this study,including 83 patients responded to CRT(response group),and 41 patients had no response to CRT(no response group).The serum ΔTBIL and ΔIBIL of response group were different compared with that of no response group(P=0.008,P=0.016).By the logistic analyze,besides gender,ICM and LBBB,the variation of total serum bilirubin was the independent predictor of the efficacy of CRT(OR=1.073,95%CI:1.006-1.144,P=0.033). Conclusion The decrease of serum total bilirubin is the independent predictor of the efficacy of CRT.
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