文章摘要
周巧,刘健,忻凌,宋倩,郭锦晨,黄旦.膝骨关节炎中医内外合治的临床数据挖掘[J].中国临床保健杂志,2018,21(1):70-74.
膝骨关节炎中医内外合治的临床数据挖掘
Clinical data-mining research of chinese medicine internal and external therapy in treating keen osteoarthritis
投稿时间:2017-03-20  
DOI:10.3969/J.issn.1672-6790.2018.01.020
中文关键词: 骨关节炎,膝  中医治疗学  数据挖掘
英文关键词: Osteoarthritis,knee  Therapeutics
基金项目:国家自然科学基金青年项目(81403388);国家临床重点专科中医风湿病科建设项目(财社[2013]239号);国家中医药重点学科中医痹病学建设项目(国中医药发[2009]30号);安徽省科技攻关项目(1301042211);安徽省自然科学基金项目(1508085QH159);安徽省重点实验室建设项目(1306c083035);安徽省重点实验室:现代中医基础与开发研究(1606c08238);安徽中医学院科技创新团队项目(2010TD005);安徽中医药大学校级基金(2014qn025)
作者单位E-mail
周巧 安徽中医药大学研究生院,合肥 230038 780149795@qq.com 
刘健 安徽中医药大学第一附属医院风湿免疫科 liujianahzy@126.com 
忻凌 安徽中医药大学第一附属医院风湿免疫科  
宋倩 安徽中医药大学研究生院,合肥 230038  
郭锦晨 安徽中医药大学研究生院,合肥 230038  
黄旦 安徽中医药大学研究生院,合肥 230038  
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中文摘要:
      目的 探讨中医药内外合治膝骨关节炎的用药特色。方法 基于临床数据挖掘技术,即采取复杂网络技术和关联规则,对安徽中医药大学第一附属医院风湿免疫科2012年6月至2015年10月膝骨关节炎住院患者的病历资料回顾性分析,根据是否采用中医外治法进行分组,对每组的一般资料、中医证型、常用中药和外用药进行分类整理,采用SPSS 22.0软件包对两组的实验室指标和临床疗效进行统计分析。结果 总共1588例,其中内外合治843例(占53.1%),单纯内治745例(占46.9%)。中药处方中以清热解毒、健脾化湿、祛风除湿、活血通络四类药为主,外治法以中药外敷为主,常用有芙蓉膏和消瘀接骨散。与治疗前相比,单纯内治和内外合治组均能降低补体C3、补体C4、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、红细胞沉降率(ESR)、超敏C反应蛋白(hs-CRP)(P<0.05或P<0.01);与单纯内治组相比,内外合治组降低补体C3、补体C4、IgG、ESR、hs-CRP水平,以及上调超氧化物歧化酶(SOD)水平方面优于单纯内治组(P<0.05或P<0.01)。结论 膝骨关节炎的内服药物以清热解毒、健脾化湿、祛风除湿、活血通络四类药为主,外用药以芙蓉膏和消瘀接骨散为主。内外合治组在降低患者体内炎症免疫反应,以及上调自由基清除剂SOD方面明显优于单纯内治组。
英文摘要:
      Objective To discuss the rapeutic character of Chinese medicine internal and exte rnal the rapy for Keen Osteoarthritis(KOA).Methods Based on clinical data mining technology and complex networkTechnology.Divided the patients into simple internal the rapy group,internal and external the rapy group,according to whether the external the rapy was used.Classfy the general data,TCM syndrome type,common Chinese medicine and external use of each group.The relationship between immune inflammation index and Clinical efficacy were analyzed by using SPSS 22.0 and Aprior module in SPSS Clementine 12.0.Results There were 1588 cases of patients with osteoarthritis,inclu-ding 843 patients (53.1%) of pure internal treatment group,745 cases (46.9%) of internal and external treatment group.Chinese herbs in prescriptions can be divided into four groups respectively,clearing away heat and toxic materials,invigorating spleen to eliminate dampness,dispelling wind and eliminating dampness,promoting blood circulation to re-move meridian obstruction.External therapy was given priority to external application,such as Furong ointment and Xi-aoyu bone powder.Compared with before treatment,simple internal governance and external governance groups could de-crease complement C3,complement C4,IgA,IgG,erythrocyte sedimentation rate(ESR),high-sensitivityC-reactive protein (hs-CRP) levels (P<0.05 or P<0.01).The internal and external combined group can reduce the levels of IgG and increase su-peroxide dismutase (SOD) levels.Comparing with the simple internal treatment,external governance group in reducing complement C3,complement C4,IgG,ESR,hs-CRP levels and increasing superoxide dismutase enzyme (SOD) levels was better than the untreated group (P<0.05 or P<0.01) .Conclusion Chinese herbs in prescriptions are priority to four groups,respectively,clearing away heat and toxic materials,invigorating spleen to eliminate damp-ness,dispelling wind and eliminating dampness,promoting blood circulation to remove meridian obstruction.External therapy is given priority to external application,such as Furong ointment and Xiaoyu bone powder.Internal and external treatment group is obviously better than simple internal treatment group in improving the inflammatory and immune re-sponses and increasing the leval of SOD.
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