文章摘要
周琳,李嘉俊,任继刚,王建,杨靖,廖雪艳.丹参川芎嗪联合替罗非班对急性ST段抬高型心肌梗死患者冠脉介入术后视黄醇结合蛋白4的影响[J].中国临床保健杂志,2018,21(1):51-54.
丹参川芎嗪联合替罗非班对急性ST段抬高型心肌梗死患者冠脉介入术后视黄醇结合蛋白4的影响
The Effficacy to retinol binding protein of salvia-chuanxiong combined with tirofiban in patients with acute ST-elevation myocardial infarction receiving percutaneous coronary intervention
投稿时间:2017-07-20  
DOI:10.3969/J.issn.1672-6790.2018.01.015
中文关键词: 心肌梗死  心肌血管重建术  视黄醇结合蛋白质类  丹参  川芎  替罗非班
英文关键词: Myocardial infarction  Myocardial revascularization  Retinol-binding proteins  Sakia miltiorrhiza  Ligusticm Chuanxiong  Tirofiban〖FL
基金项目:四川省科技支撑计划(2013SZ0082)
作者单位E-mail
周琳 四川成都市第六人民医院心血管内科,610051 zhoulin_78@126.com 
李嘉俊 四川成都市第一人民医院超声科  
任继刚 四川成都市第六人民医院心血管内科,610051  
王建 四川成都市第六人民医院心血管内科,610051  
杨靖 四川成都市第六人民医院心血管内科,610051  
廖雪艳 四川成都市第六人民医院心血管内科,610051  
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中文摘要:
      目的 探讨丹参川芎嗪联合半剂量替罗非班对急性ST段抬高型心肌梗死(STEMI) 患者经皮冠脉介入治疗(PCI)术后血清视黄醇结合蛋白4(RBP4)水平及临床缺血事件的影响。方法 按分层随机化法将130例行PCI手术的STEMI患者,分为两组,对照组60例PCI术后常规治疗,观察组70例另给予半剂量替罗非班维持48 h联合丹参川芎嗪注射液治疗7 d。并统计术后相关指标(7d RBP4及肾小球滤过率、肌钙蛋白T)及术后半年的临床缺血事件(复合缺血及出血事件、冠脉TIMI血流)。结果 术后7 d,观察组较对照组的RBP4、肌钙蛋白T(CTnT)平均值均有下降(P<0.05),肾小球滤过率(GFR)有升高(P<0.05);未增加半年的缺血与出血事件(P>0.05)。结论 使用丹参川芎嗪联合半剂量替罗非班可降低STEMI患者PCI术后RBP4水平,改善患者肾功能及心肌的缺血坏死,且不增加出血风险。
英文摘要:
      Objective To investigate the effect of Salvia miltiorrhiza Ligustrazine combined with half dose tirofiban on the postoperative serum retinol binding protein 4 (RBP4) level and clinical ischemic events in acute ST elevation myocardial infarction (STEMI) patients who recevied percutaneous coronary intervention (PCI).Methods Stratified randomization method was adpoted to divede 130 cases underwent PCI STEMI into two groups,60 cases in the control group after PCI treated with conventional treatment,70 cases in observation group were given the other half dose tirofiban treatment 48h combined with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection 7d.The postoperative related indexes (7d,RBP4 and glomerular filtration rate,troponin T) and clinical ischemic events (ischemia and hemorrhage events,coronary TIMI blood flow) were evaluated.Results The mean value of serum RBP4 and CTnT in the observation group decreased and GFR increased compared with the control group on the 7 day after operation,Ischemic and hemorrhagic events did not show significant difference for half a year.Conclusion The use of Danshen Ligustrazine combined with half dose tirofiban in patients with PCI can reduce the level of RBP4 in patients with STEMI,improve the renal function and myocardial ischemia without increasing the risk of bleeding.
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