文章摘要
张宣宣,王卫东,王靖秋,李金生,张世阳.银杏叶提取物注射液对老年2型糖尿病患者并发脑梗死事件的一级预防作用[J].中国临床保健杂志,2018,21(1):18-21.
银杏叶提取物注射液对老年2型糖尿病患者并发脑梗死事件的一级预防作用
The primary preventive effect of extract of Ginkgo Biloba Leaves injection on cerebral infarction in elderly patients with type 2 diabetes
投稿时间:2017-11-10  
DOI:10.3969/J.issn.1672-6790.2018.01.006
中文关键词: 糖尿病,血管病变;银杏内酯类  银杏素;脑梗死
英文关键词: Diabetes mellitus,angiopathies  Bilobalides  Ginkgetin  Brain infarction 〖FL
基金项目:安徽省自然基金课题(1408085MH208)
作者单位E-mail
张宣宣 安徽医科大学附属省立医院、安徽省立医院老年医学科,合肥230001 411181919@qq.com 
王卫东 安徽医科大学附属省立医院、安徽省立医院老年医学科,合肥230001 13505519153@163.com 
王靖秋 安徽医科大学附属省立医院、安徽省立医院老年医学科,合肥230001  
李金生 安徽医科大学附属省立医院、安徽省立医院老年医学科,合肥230001  
张世阳 安徽医科大学附属省立医院、安徽省立医院老年医学科,合肥230001  
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中文摘要:
      探讨银杏叶提取物注射液对老年2型糖尿病患者并发脑梗死的一级预防作用。〖HT5"H〗方法〓〖HT5"F〗选取80例老年糖尿病患者,按照随机数字表法分为观察组和对照组,每组各40例。对照组采取常规治疗,观察组在常规治疗的基础上加用银杏叶提取物注射液治疗2个疗程。观察两组治疗前后炎性因子水平、药物不良反应,及随访并发脑梗死患病率。〖HT5"H〗结果〓〖HT5"F〗炎性因子:观察组白介素 6(IL 6)[(25.01±7.99)ng/L]明显低于对照组(〖WTBX〗P〖WTBZ〗<0.05)、肿瘤坏死因子(TNF α)[(39.22±9.69)ng/L]明显低于对照组(〖WTBX〗P〖WTBZ〗<0.05)、脂联素(APN)[(12.06±2.92)mg/L]明显高于对照组(〖WTBX〗P〖WTBZ〗<0.05);并发脑梗死情况:观察组并发脑梗死患病率(2.5%)明显低于对照组(20%)(〖WTBX〗P〖WTBZ〗<0.05);不良反应:两组不良反应差异无统计学意义(〖WTBX〗P〖WTBZ〗>0.05)。〖HT5"H〗结论〓〖HT5"F〗银杏叶提取物注射液可抑制老年2型糖尿病患者炎性反应,降低脑梗死患病率。
英文摘要:
      Objective To study the primary preventive effect of extract of ginkgo biloba leaves injection on cerebral infarction in elderly patients with type 2 diabetes.Methods A total of 80 cases patients with elderly diabetes patients were divided into observation group(40 cases)and control group(40 cases).The control group were given routine treatment,the observation group were given extract of ginkgo biloba leaves injection based on routine treatment for 30d all.Inflammatory factors and adverse drug reactions,incidence of cerebral infarction to type 2 diabetes in elderly were compared.Results In observation group IL-6[(25.01±7.99)pg/L],TNF-α[(39.22±9.69)mg/L],were significantly lower than control group.Serum APN[(12.06±2.92)mg/L] was significantly higher than that of control group.In observation group incidence of diabetes mellitus complicated with cerebral infarction(2.5%) was significantly lower than that of control group(20%).There was no significant difference in adverse drug reactions between two groups.Conclusion The extract of ginkgo biloba leaves can inhibit inflammatory reaction,and reduce incidence of cerebral infarctionin in elderly type 2 diabetes.
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